职业病危害及经济损失

我国工业职业病危害严重，造成的经济损失巨大，约占年国民经济总产值的２．５％以上，加强对职业病危害的预防、控制，以减少损失十分必要。为保证我国经济建设的顺利进行，必须完善立法，用经济手段强化对职业病的预防、监控和管理。     

Differences in sensitivity to the fungal pathogen Batrachochytrium dendrobatidis among amphibian populations

Contributing to the worldwide biodiversity crisis are emerging infectious diseases, which can lead to extirpations and extinctions of hosts. For example, the infectious fungal pathogen Batrachochytrium dendrobatidis (Bd) is associated with worldwide amphibian population declines and extinctions. Sensitivity to Bd varies with species, season, and life stage. However, there is little information on whether sensitivity to Bd differs among populations, which is essential for understanding Bd‐infection dynamics and for formulating conservation strategies. We experimentally investigated intraspecific differences in host sensitivity to Bd across 10 populations of wood frogs (Lithobates sylvaticus) raised from eggs to metamorphosis. We exposed the post‐metamorphic wood frogs to Bd and monitored survival for 30 days under controlled laboratory conditions. Populations differed in overall survival and mortality rate. Infection load also differed among populations but was not correlated with population differences in risk of mortality. Such population‐level variation in sensitivity to Bd may result in reservoir populations that may be a source for the transmission of Bd to other sensitive populations or species. Alternatively, remnant populations that are less sensitive to Bd could serve as sources for recolonization after epidemic events.     

Effects of white‐nose syndrome on regional population patterns of 3 hibernating bat species

Hibernating bats have undergone severe recent declines across the eastern United States, but the cause of these regional‐scale declines has not been systematically evaluated. We assessed the influence of white‐nose syndrome (an emerging bat disease caused by the fungus Pseudogymnoascus destructans, formerly Geomyces destructans) on large‐scale, long‐term population patterns in the little brown myotis (Myotis lucifugus), the northern myotis (Myotis septentrionalis), and the tricolored bat (Perimyotis subflavus). We modeled population trajectories for each species on the basis of an extensive data set of winter hibernacula counts of more than 1 million individual bats from a 4‐state region over 13 years and with data on locations of hibernacula and first detections of white‐nose syndrome at each hibernaculum. We used generalized additive mixed models to determine population change relative to expectations, that is, how population trajectories differed with a colony's infection status, how trajectories differed with distance from the point of introduction of white‐nose syndrome, and whether declines were concordant with first local observation of the disease. Population trajectories in all species met at least one of the 3 expectations, but none met all 3. Our results suggest, therefore, that white‐nose syndrome has affected regional populations differently than was previously understood and has not been the sole cause of declines. Specifically, our results suggest that in some areas and species, threats other than white‐nose syndrome are also contributing to population declines, declines linked to white‐nose syndrome have spread across large geographic areas with unexpected speed, and the disease or other threats led to declines in bat populations for years prior to disease detection. Effective conservation will require further research to mitigate impacts of white‐nose syndrome, renewed attention to other threats to bats, and improved surveillance efforts to ensure early detection of white‐nose syndrome.     

Carrier detection and prenatal diagnosis in Norrie disease

We report the use of DNA probes to determine carrier status in three young women from a large kindred with Norrie disease. One of the women requested prenatal diagnosis during pregnancy. In this pedigree, Norrie disease was not characterized by a deletion at DXS7.     

First trimester prenatal diagnosis of Sanfilippo disease (MPSIII) type B

Two pregnancies of a family at risk for Sanfilippo disease type B were monitored in the first trimester. In one case an affected fetus was diagnosed on chorionic villi by the assay of N-acetyl-a-D -glucosaminidase and confirmed on cultured fibroblasts from the aborted fetus. Pathological findings are also reported and compared with changes observed later in life. The disease was excluded in the second pregnancy.     

Prenatal diagnosis for Tay-Sachs disease using chorionic villus sampling

Prenatal diagnosis for Tay-Sachs disease was performed on 25 patients using chorionic villus sampling (CVS). Nineteen were diagnosed as normal, and six were affected. Normal villus extracts had both hexosaminidase (hex) A and B activity, as determined by Cellogel and polyacrylamide gel electrophoresis, while extracts from affected fetuses had only hex B activity. Compared to cultured amniotic fluid cells or fibroblasts, villi contained less hex A. Hex A levels in fresh villi and cultured trophoblasts were roughly comparable.     

The discovery of ash dieback in the UK: the making of a focusing event

Why did the identification of ash dieback (Chalara Fraxinea) in 2012 in the UK catch the national media, public, and political zeitgeist, and lead to policy changes, in a way that no other contemporary tree pest or pathogen outbreak has? The identification of ash dieback in the UK is conceptualised as a successful ‘focusing event’, and the ways in which it was socially constructed by the media, stakeholders, and the government are analysed. National newspaper coverage contributed to the way that the disease was understood and was significant in driving the political response. Ash dieback’s focal power derived from the perceived scale and nature of its impact, the initial attribution of blame on government, the war-like response from the government, and Ash’s status as a threatened native tree. The ash dieback focusing event has increased the salience of plant health issues amongst policymakers, the public, and conservation organisations in the UK.     

马铃薯糖苷生物碱的生物学作用及开发利用

本文根据作者近年的研究成果及国外研究动态，简要介绍了马铃薯糖苷生物碱的种类，结构，含量及在植株中的分布；重点论述了糖苷生物碱的毒性，毒理及对块茎食用、饲用和加工品质的影响，糖苷生物碱与马铃薯植株自身的抗病，抗虫性及其抗病虫育种的关系，以及糖苷生物碱在医药学中的应用价值，为马铃薯的综合开发利用指出了新途径。     

DETERMINING THE RELATIONSHIP BETWEEN WATER QUALITY AND INFECTIOUS DISEASE IN FISHERY POPULATIONS1

ABSTRACT: Diseases in wild fish populations may have multiple economic and social impacts. Epidemics of infectious diseases, which are associated with the presence of some microbe or parasite, have recently been observed in several major estuarine systems in the eastern United States. The most prevalent of these problems is ulcerative mycosis (UM), a fungal infection. The agents responsible for UM and many of these other diseases are opportunistic pathogens that are not believed to infect normal, immunocompetent individuals. While inroads have been made into determining the infectious agents associated with these diseases, we know very little of how pollution may influence their prevalence. Understanding the importance of pollution requires an awareness of all the environmental conditions that can affect the health of wild populations. In this paper, a multistep examination of the interactions between the host, pathogen(s), and environment is outlined.