K. Spencer  I. Staboulidou  K. H. Nicolaides 《黑龙江环境通报》2010,30(3):235-240

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Kevin Spencer 《黑龙江环境通报》2002,22(10):874-876

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Kevin Spencer 《黑龙江环境通报》2001,21(6):445-447

In a group of 149 women who had undergone routine first trimester screening using fetal nuchal translucency thickness (NT) and maternal serum free β-hCG and pregnancy associated plasma protein-A (PAPP-A) in two consecutive pregnancies the within person between pregnancy biological variability of these markers has been assessed. For fetal NT there was no correlation between NT MoM in the first and second pregnancy (r=0.0800). For maternal serum free β-hCG MoM a significant correlation was observed (r=0.4174) as was also found for PAPP-A MoM (r=0.3270). The implications for such between pregnancy marker association is that women who have an increased risk of Down syndrome in their first pregnancy are 1.5–2 times more likely to repeat this event in their next pregnancy. This observation may be useful in counselling women in the first trimester screening of a subsequent pregnancy. Copyright © 2001 John Wiley & Sons, Ltd.  相似文献   

    

W. F. Carey  A. Poulos  P. Sharp  P. V. Nelson  E. F. Robertson  J. L. Hughes  A. Gill 《黑龙江环境通报》1994,14(9):813-819

Variability in the level of expression of very long chain fatty acids (VLCFAs) is documented in cultured chorionic villus (CV) cells derived from two fetuses, one at risk for an unusual peroxisomal fatty acid β-oxidation defect, and the other at risk for the X-linked form of adrenoleucodystrophy (ALD). Cells from early subcultures of chorionic cells from both cases gave normal values for VLCFA ratios. The results for the fetus at risk for the β-oxidation defect were interpreted to indicate that the fetus was not affected; however, at birth, the infant was clinically and biochemically affected. In the case of the fetus at risk for X-linked ALD, although VLCFAs were normal in subculture 1, the levels of these fatty acids increased dramatically in subculture 3, suggesting an abnormal fetus. Termination of the pregnancy and subsequent biochemical and morphological follow-up confirmed that the fetus was indeed affected by ALD.  相似文献   

    

M. A. J. Engels  M. Kooij  R. Schats  J. W. R. Twisk  M. A. Blankenstein  J. M. G. van Vugt 《黑龙江环境通报》2010,30(4):372-377

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Marko Niemimaa  Mikko Suonpää  Seppo Heinonen  Maija Seppälä  Risto Bloigu  Markku Ryynänen 《黑龙江环境通报》2002,22(3):183-185

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Kevin Spencer  Nicholas J. Cowans  Anastasia Stamatopoulou 《黑龙江环境通报》2008,28(5):422-424

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Michael Christiansen  Kevin Spencer  Jennie Laigaard  Nicholas J. Cowans  Severin Olesen Larsen  Ulla M. Wewer 《黑龙江环境通报》2007,27(7):611-615

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Kevin Spencer  Adolfo W. Liao  Charas Y. T. Ong  Lut Geerts  Kypros H. Nicolaides 《黑龙江环境通报》2001,21(9):718-722

Placenta growth factor (PIGF), an angiogenic factor belonging to the vascular endothelial growth factor family, pregnancy-associated plasma protein A (PAPP-A) and free β-human chorionic gonadotrophin (β-hCG) were measured in maternal serum from 45 pregnancies with trisomy 21, 45 with trisomy 18 and 493 normal controls at 10–13 completed weeks of gestation. In the normal pregnancies maternal serum PIGF levels increased exponentially with gestation. The median multiple of the median (MoM) PIGF concentration in the trisomy 21 group (1.26 MoM) was significantly higher (p<0.0001) than in the control group (1.00 MoM). In the trisomy 18 group the median PIGF was lower (0.889 MoM) but this did not quite reach significance (p=0.064). The corresponding median MoM values for PAPP-A were 1.00 MoM for the controls, 0.49 MoM for trisomy 21 and 0.16 MoM for trisomy 18. The median MoM values for free β-hCG were 1.00 MoM for the controls, 2.05 MoM for trisomy 21 and 0.38 MoM for trisomy 18. In the control group there was a small but significant correlation of PIGF with free β-hCG (r=+0.1024) and PAPP-A (r=+0.2288). In the trisomy 18 group there was a significant association between PIGF and free β-hCG (r=+0.2629) but not with PAPP-A (r=+0.0038). In the trisomy 21 group there was a small but significant association with PAPP-A (r=+0.1028) but not with free β-hCG (r=+0.0339). The separation of affected and unaffected pregnancies in maternal serum PIGF is small, and therefore it is unlikely that measurement of PIGF would improve screening for these abnormalities provided by the combination of fetal nuchal translucency and maternal serum PAPP-A and free β-hCG. Copyright © 2001 John Wiley & Sons, Ltd.  相似文献   

    

Simona Cicero  Kevin Spencer  Kyriaki Avgidou  Stefano Faiola  Kypros H. Nicolaides 《黑龙江环境通报》2005,25(11):977-983

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