Maternal age specific rates for chromosome aberrations and factors influencing them: Report of a collaborative european study on 52 965 amniocenteses

Maternal age specific rates for all major chromosome aberrations have been determined in 52 965 pregnancies in mothers 35 years of age and over at the time of amniocentesis. Rates increase exponentially with advancing maternal age for trisomies 21, 18 and 13, and for the XXX and XXY syndromes, but in the autosomal trisomies this rise appears to be followed by a levelling off at the upper end of the age range. A significant inverse relationship with maternal age is found for 45,X cases. It is postulated that these various patterns are the result of the interaction of three principal factors: a maternal age effect acting particularly on first meiotic nondisjunction: a higher spontaneous abortion rate with advancing maternal age for aneuploid as compared to euploid conceptions; and an increased probability of spontaneous abortion before the time of amniocentesis for conceptions with more extensive chromosome imbalance. A stepwise logistic regression analysis of 13 299 pregnancies in which both parental ages are known shows that the father's age does not influence these maternal age specific rates, with the possible exception of the 47,XXY syndrome.     

浅析木制品加工对环境的影响

我国森林覆盖率为16.55％,人均森林面积约为世界平均水平的1/5,为少林国家。而现有木材加工企业利用率不高,加之木制品的大量出口,使森林遭到更大破坏。应采取提高木材综合利用率水平、培育速生丰产林种、以竹代木、调整林产企业产业结构等措施减小对环境的不良影响。     

辛基酚的体内类雌激素活性评价

利用体内大鼠子宫增重试验检测辛基酚（OP）的类雌激素活性，并对其观测终点及影响因素进行了初步研究。结果显示，OP经大鼠体内染毒，可引起大鼠子宫湿重、子宫内皮细胞厚度、子宫腺数量明显增加，具有明显的类雌激素活性。三条染毒途径检测敏感度腹腔染毒＞经皮下染毒＞经灌胃染毒。     

两种奥氏体不锈钢酸性盐雾腐蚀行为研究

目的研究0Cr18Ni9(钝化)不锈钢与0Cr18Ni10Ti(钝化)不锈钢在酸性盐雾条件下的腐蚀行为,为发动机零件选材及防护措施的改进提供依据。方法按GJB150.11A—2009《军用装备环境试验方法盐雾试验》进行,调节溶液p H到3.5±0.5,以24 h喷雾润湿+24 h干燥为一个循环,分别开展2(96 h)、4(192 h)、5(240 h)个循环的酸性盐雾试验。采用目视、称量、X射线衍射(XRD)、扫描电子显微镜(SEM)及能谱仪(EDS)对盐雾腐蚀后试样进行观察及分析。结果 0Cr18Ni9(钝化)与0Cr18Ni10Ti(钝化)两种奥氏体不锈钢均发生了轻微的腐蚀,主要为局部腐蚀及均匀腐蚀。结论两种金属在酸性盐雾条件下耐蚀性良好,且可满足目前海军型发动机对材料耐酸性盐雾腐蚀的要求,0Cr18Ni9(钝化)略优于0Cr18Ni10Ti(钝化)。     

公路设计中的环境保护工作

阐述了公路建设中环境保护工作的意义，提出在公路工程勘察设计工作中对环境保护的典型作法和取得的效果。     

小凌河污水灌溉对水稻作物影响的分析

通过小凌河水灌溉水稻的清水不地比清沙漠为分析污灌给水稻作物带来的生长发育，产量及稻米品质等方面的生态效应，初步了解米质品质下降的不利因素，并提出审慎考虑污灌问题。     

会计集中核算的实践与思考

会计集中核算是会计管理体制改革的一项举措,从试点单位初步运行情况看,其作用明显,产生了较好的社会效益和经济效益,为防止各种违纪行为筑起了一道坚固的防线。虽然会计集中核算有一定的局限性,但它作为会计管理体制改革的一项有益尝试,应在有条件的部门积极推行     

Human exposure to a mixture of endocrine disruptors and serum levels of thyroid hormones: A cross-sectional study

Exposure to endocrine disruptors (EDCs) could disrupt thyroid hormone homeostasis. However, human epidemiological studies reported inconsistent observations, and scarce information on the effect of a mixture of chemicals. The aim of the present study was to examine the associations of multiple chemicals with thyroid hormones among adults from China. We measured serum levels of thyroid hormones and urinary levels of 11 EDCs, including six phthalate metabolites, bisphenol A (BPA), bisphenol F (BPF), bisphenol S (BPS), perchlorate, and thiocyanate among 177 healthy adults without occupational exposure. Associations of multiple urinary analytes with serum thyroid hormones were examined by performing general linear regression analysis and bayesian kernal machine regression analysis. These EDCs were detected in almost all samples. After adjusting for various covariates, we observed only BPF significantly associated with total thyroxin (TT4) (β=-0.27, 95% confidence interval (CI) [-0.41, -0.14]), total triiodothyronine (TT3) (β=-0.02 95% CI [-0.03, -0.01]), free T4 (fT4) (β=-0.02, 95% CI [-0.03, -0.01]), and free T3 (fT3) (β=-0.04, 95% CI [-0.07, -0.01]), and mono-(2-ethyl-5-oxohexyl) phthalate (MEOHP) and monoethyl phthalate (MEP) positively associated with TT4 (β=0.24, 95% CI [0.01, 0.48]) and fT4 (β=0.02, 95% CI [0.01, 0.04]), respectively. Moreover, we observed significant dose-response relationships between TT4 and the mixture of 11 EDCs, and BPF was the main contributor to the mixture effect, suggesting the priority of potential effect of BPF on disrupting thyroid function under a real scenario of human exposure to multiple EDCs. Our findings supported the hypothesis that human exposure to low levels of EDCs could alter thyroid hormones homeostasis among non-occupational healthy adults.     

钻井泥浆和消油剂对合浦珠母贝的急性毒性效应

采用96h急性毒性试验配合滤食率和微核检测等方法，比较了石油勘探开发用3种钻井泥浆和3种消油剂对合浦珠母贝成贝急性毒性效应。实验结果表明：3种钻井泥浆对合浦珠母贝的半致死浓度均大于10^5mg/L；3种消油剂的半致死浓度分别为1047、5011和2630mg/L；滤食率与钻井泥浆和消油剂的浓度呈负相关；微核细胞率则与之呈正相关。     

涡凹气浮机在炼油污水处理中的应用

对涡凹气浮机在炼油污水气浮工艺的改造的应用进行了总结，改造后该气浮机具有投资省、运行费用低、操作维护简单、工作效率高等优点，且运行稳定，效果比较理想，应用前景十分广阔。