Structural chromosomal mosaicism and prenatal diagnosis

True structural chromosomal mosaicism are rare events in prenatal cytogenetics practice and may lead to diagnostic and prognostic problems. Here is described the case of a fetus carrying an abnormal chromosome 15 made of a whole chromosome 2p translocated on its short arm in 10% of the cells, in association with a normal cell line. The fetal karyotype was 46,XX,add(15)(p10).ish t(2;15)(p10;q10)(WCP2+)[3]/46,XX[27]. Pregnancy was terminated and fetus examination revealed a growth retardation associated with a dysmorphism including dolichocephaly, hypertelorism, high forehead, low-set ears with prominent anthelix and a small nose, which were characteristic of partial trisomy 2p. Possible aetiologies for prenatal mosaicism involving a chromosomal structural abnormality are discussed. Copyright © 2004 John Wiley & Sons, Ltd.     

丹江口水库水质要素变化特征及其相互关系

采用丹江口水库 1987～ 1996年间的水环境常规监测资料 ,应用因子分析方法探讨了丹江口水库不同区域水环境要素变化特征及其相互关系 ,分析表明 :丹江口水库目前水质良好 ,大多数情况下能满足地面水一类水质标准要求 :库区不同断面水体水质要素及污染因子间的相互关系可以用 6个主导因子表达。同一主导因子不同断面标识因子的差异反映了库区不同区域水质分布差异及产生这种差异的环境过程 ;影响库区水质的主要因素是上游随降水产生的面源污染、库周点源排放、水体自净以及气候因素 ,不同断面水质影响因素及其程度存在差异。     

A stochastic-advective transport model for NAPL dissolution and degradation in non-uniform flows in porous media

Remediation schemes for contaminated sites are often evaluated to assess their potential for source zone reduction of mass, or treatment of the contaminant between the source and a control plane (CP) to achieve regulatory limits. In this study, we utilize a stochastic stream tube model to explain the behavior of breakthrough curves (BTCs) across a CP. At the local scale, mass dissolution at the source is combined with an advection model with first-order decay for the dissolved plume. Field-scale averaging is then employed to account for spatial variation in mass within the source zone, and variation in the velocity field. Under the assumption of instantaneous mass transfer from the source to the moving liquid, semi-analytical expressions for the BTC and temporal moments are developed, followed by derivation of expressions for effective velocity, dispersion, and degradation coefficients using the method of moments. It is found that degradation strongly influences the behavior of moments and the effective parameters. While increased heterogeneity in the velocity field results in increased dispersion, degradation causes the center of mass of the plume to shift to earlier times, and reduces the dispersion of the BTC by lowering the concentrations in the tail. Modified definitions of effective parameters are presented for degrading solutes to account for the normalization constant (zeroth moment) that keeps changing with time or distance to the CP. It is shown that anomalous dispersion can result for high degradation rates combined with wide variation in velocity fluctuations. Implications of model results on estimating cleanup times and fulfillment of regulatory limits are discussed. Relating mass removal at the source to flux reductions past a control plane is confounded by many factors. Increased heterogeneity in velocity fields causes mass fluxes past a control plane to persist, however, aggressive remediation between the source and CP can reduce these fluxes.     

Contribution of anthropogenic pollutants to the increase of tropospheric ozone levels in the Oporto Metropolitan Area, Portugal since the 19th century

The main purpose of this study was to evaluate the contribution of anthropogenic pollutants to the increase of tropospheric ozone levels in the Oporto Metropolitan Area (Portugal) since the 19th century. The study was based on pre-industrial and recent data series, the results being analyzed according to the atmospheric chemistry. The treatment of ozone and meteorological data was performed by classical statistics and by time-series analysis. It was concluded that in the 19th century the ozone present in the troposphere was not of photochemical origin, being possible to consider the respective concentrations as reference values. For recent data a cycle of 8h for ozone concentrations could be related to traffic. Compared to the 19th century, the current concentrations were 147% higher (252% higher in May) due to the increased photochemical production associated with the increased anthropogenic emissions.     

钢筋混凝土旧工业厂房主体结构的改造加固风险研究

为探索钢筋混凝土旧工业厂房的改造与加固风险,进行了实地调研和基础理论研究,借助SPSS 22.0统计软件对32个二级指标进行筛选,确立6个方面29个指标的改造加固风险评价指标体系,运用结构方程模型（SEM）实证分析关键影响因素及其作用路径。研究结果表明:设计方案、结构特征和施工技术对改造加固风险具有影响;结构特征与设计方案之间的强关联形成了隐性且重要的风险路径。基于关键影响因素及因素间关联关系,对宝鸡市某U型厂房主体结构加固实例提出建议,为此类项目的改造施工提供理论依据。     

建筑安全事故防范认知与主体身份特征关系诊断研究

为进一步研究建筑安全主体的身份特征对建筑安全事故防范认知的影响,通过分析现有文献,对建筑安全主体身份特征、建筑安全管理认知、建筑安全技术措施认知和建筑安全事故防范认知4个因素分别进行探讨,并提出其相互之间的关系假设。基于结构方程模型(SEM)方法,构建由4个因子16个观测变量组成的指标体系。采用LISREL8.53软件,验证因子及观测变量之间的关系。个案研究结果表明,主体身份特征对建筑安全管理认知、安全技术措施认知和建筑安全事故防范认知具有较强的社会属性效应,主体身份特征通过建筑安全管理认知、安全技术措施认知对建筑安全事故防范认知的正效应也比较明显。重塑建筑安全主体社会属性、加强安全管理和技术措施教育,均能有效提高建筑安全事故防范认知。     

基于时变失效的桥式起重机结构可靠性分析

为提高我国起重机产品的安全可靠性水平,用时变可靠性理论分析桥式起重机金属结构。以桥式起重机金属结构为研究对象,时变可靠性理论为基础,研究桥式起重机金属结构的载荷时变可靠性模型和抗力时变可靠性模型,建立桥式起重机金属结构失效状态的时变可靠性数学模型。通过工程算例分析,揭示金属结构抗力随时间衰减与否对可靠度与失效概率的影响,得到不同金属结构抗力衰减系数下桥式起重机主梁金属结构可靠度和失效概率。探索桥式起重机金属结构时变可靠性安全评估方法。对比金属结构抗力衰减系数分别为0.000 2和0.000 3时的分析结果,发现金属结构系统的可靠性随金属结构抗力衰减系数的增加而降低。     

膨胀聚苯乙烯热分解动力学分析和寿命预测

针对既有聚苯乙烯泡沫类外墙外保温系统的防火问题,在空气和氮气气氛下对非阻燃和阻燃型膨胀聚苯乙烯泡沫进行了热重分析。样品由10℃/min、20℃/min、40℃/min和50℃/min四个升温速率从室温加热至800℃。热分解动力学参数由Flynn-Wall-Ozawa(FWO)等转化率方法和多参数非线性回归方法(multivariate non-linear re-gression method)计算,结果表明六溴环十二烷(HBCD)阻燃剂可一定程度上提高EPS的热稳定性。EPS在空气和氮气气氛下热解可认为是单步反应。非阻燃聚苯乙烯泡沫在空气和氮气气氛下的热解过程可由自催化n阶反应机理描述。阻燃EPS在空气气氛下的热解机理为自催化n阶反应,在氮气气氛下则为n阶反应机理。基于动力学参数和反应机理,对聚苯乙烯泡沫在不同温度下的寿命进行了预测。     

Investigating the effect of geometric dimensions of median traffic barriers on crashes: Crash analysis of interstate roads in Wyoming using actual crash datasets

IntroductionDespite the numerous safety studies done on traffic barriers’ performance assessment, the effect of variables such as traffic barrier’s height has not been identified considering a comprehensive actual crash data analysis. This study seeks to identify the impact of geometric variables (i.e., height, post-spacing, sideslope ratio, and lateral offset) on median traffic barriers’ performance in crashes on interstate roads.MethodGeometric dimensions of over 110 miles median traffic barriers on interstate Wyoming roads were inventoried in a field survey between 2016 and 2018. Then, the traffic barrier data collected was combined with historical crash records, traffic volume data, road geometric characteristics, and weather condition data to provide a comprehensive dataset for the analysis. Finally, an ordered logit model with random-parameters was developed for the severity of traffic barrier crashes. Based on the results, traffic barrier’s height was found to impact crash severity.ResultsCrashes involving cable barriers with a height between 30″ and 42″ were less severe than other traffic barrier types, while concrete barriers with a height shorter than 32″ were more likely involved with severe injury crashes. As another important finding, the post-spacing of 6.1–6.3 ft. was identified as the least severe range in W-beam barriers.Practical applicationsThe results show that using flare barriers should reduce the number of crashes compared to parallel barriers.