Prenatal diagnosis of NADH:ubiquinone oxidoreductase deficiency

NADH:ubiquinone oxidoreductase (complex I of the mitochondrial respiratory chain) deficiency is a severe disorder with an often early fatal outcome. Prenatal diagnosis for complex I defects currently relies mainly on biochemical assays of complex I in fetal tissues such as chorionic villi (CV), and is only in a minority of cases possible by means of mutational analysis of nuclear-encoded genes of complex I. We report on our experience to date with prenatal diagnosis in pregnancies at risk for complex I deficiency. We measured complex I activity in native CV and/or cultured CV in 23 pregnancies in 15 families. In accordance with the results of the investigations in CV, 15 children were born clinically unaffected. Two prenatally diagnosed unaffected fetuses and two prenatally diagnosed affected fetuses were lost prematurely with spontaneous or provoked abortions, respectively. Two affected children were born (prenatally found to be affected). In two pregnancies a discrepancy between native and cultured cells was found. We conclude that prenatal diagnosis for complex I deficiency can be reliably performed. Pitfalls were encountered in using cultured CV as a result of maternal cell contamination (MCC). Future research on pathogenic nuclear mutations underlying complex I deficiency will extend the possibilities for prenatal diagnosis at the molecular level. Copyright © 2001 John Wiley & Sons, Ltd.     

广东土地抗蚀潜势初步研究

利用计算机和地理信息系统软件．研究了广东省的土壤质地、土壤有机质、地势三个侵蚀因子对土壤侵蚀方面的影响，指出了广东土地抗蚀性极弱地区主要是湛江市、新丰县的小部分地区，而抗蚀性弱的区域则很大，约占全省土地面积的49．8％，遍布全省中部和南部．针对这样的现状，提出要减少抗蚀性弱和极弱地区的土壤侵蚀，必须做到：对土地的利用开垦进行统一规划；严禁乱伐森林；采取生物措施和工程措施相结合的方式防治土壤侵蚀的进一步变化．     

Floating Population Increase and Its Influence on the Urban Population Situation:A Case Study in Beijing

1 BACKGROUND OF FLOATING POPULATIONIN CHINAChina's urbanization process was influenced mainly bythe government interventions before the adoption of thesocial and economic reform started in 1978. Since thefoundation of the People's Republic of China, thegovernment had strictly controlled the internal migration,especially from rural to urban areas. The ability of thegovernment to make a strong impact on the migrationand urbanization was realized by the household registrationsyste…     

Using many-objective trade-off analysis to help dams promote economic development,protect the poor and enhance ecological health

Allocating water to different uses implies trading off the benefits perceived by different sectors. This paper demonstrates how visualising the trade-offs implied by the best performing water management options helps balance water use benefits and find sustainable solutions. The approach consists of linking a water resources model that can simulate many management policies and track diverse measures of system performance, to a many-objective evolutionary optimisation algorithm. This generates the set of Pareto-optimal management alternatives for several simultaneous objectives. The relative performance of these efficient management alternatives is then visualised as trade-off curves or surfaces using visual analytic plots. Visually assessing trade-offs between benefits helps select policies that achieve a decision-maker-selected balance between different metrics of system performance. We apply this approach to a multi-reservoir water resource system in Brazil's semi-arid Jaguaribe basin where current water allocation procedures favour sectors with greater political power and technical knowledge. The case study identifies promising reservoir operating policies by exploring trade-offs between economic, ecological and livelihood benefits as well as traditional hydropower generation, irrigation and water supply. Results show optimised policies can increase allocations to downstream uses while increasing median land availability for the poorest farmers by 25%.     

焦作市城市社会生态环境评价

在调查研究的基础上，针对焦作市2000年的城市生态环境现状，构建了城市社会生态环境质量评价体系，由3个层次24个指标组成。对焦作市城市社会生态环境进行单因素和综合质量评价。评价结果表明，该市的城市社会生态环境质量比较差，并存在一些主要社会生态环境问题。最后，针对性地提出了一些改善治理的对策。     

"一退两还"中的博弈分析与制度创新

“一退两还”即“退耕还林还草”，是我国政府在世纪之交所作出的一项旨在推进国民经济可持续发展的战略举措。本文运用博弈论的方法，通过对“一退两还”中的各个相关主体利益的思考和行为的辨析，结合分析结论，提出了对提高“一退两还”实施效果具有重要意义的制度创新思路。     

区域持续发展与地理信息系统的协调作用

环境与发展是当今人类社会所面临的两大主题,已引起各国政府和国际社会的广泛关注。持续发展代表了一种新的发展战略和我们从事经济活动的新方法。地理信息系统技术具有综合各种社会、经济和环境因素的能力,为科学决策和实现区域持续发展提供了一种强有力的工具。同时,地理信息系统为在区域持续发展中利用生态学方法、时序分析和科学决策提供了强有力的技术支持。在我国,区域持续发展已引起了越来越多的研究机构与政府部门的重视。应该注意到,实现这一目标离不开地理信息系统技术的支持。本文主要讨论地理信息系统对区域持续发展的作用和探讨建立区域持续发展的地理信息系统的理论模式。     

论SSP范式在环境保护结构绩效分析中的应用--以体制转型时期为例的研究

文章是将美国经济学家A.爱伦·斯密德的SSP分析范式运用于环境保护结构绩效研究的一次新的尝试.首先指出了斯密德的SSP范式与以往环境保护绩效研究工具的不同之处,适时给出了将SSP范式运用于环境保护结构绩效分析的几个理由.最后,本文将SSP范式运用于我国体制转型时期环境保护结构绩效的分析.     

我国资源与环境信息系统建立与应用

资源与环境信息系统是研究人口、资源与环境的重要工具。本文论述了其定义和意义,说明其在我国发展的情况,以及应用上的特点,提出其建立与应用的广阔前景。