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Thyroid hormones, which influence body metabolism and development, could be affected by persistent organic pollutants. We sought to examine the relationship between polybrominated biphenyls (PBBs) and polychlorinated biphenyls (PCBs) and thyroid disease. We employed incidence density sampling to perform a nested case control analysis of the Michigan Long-Term PBB Cohort. Cohort members (n = 3333) were exposed to PBBs through contaminated cattle feed in 1973-1974 and to PCBs through daily life. Those with detectable serum PBB and PCB concentrations at enrollment were categorized into tertiles of PBB and PCB exposure. Case-patients were cohort members answering “Yes” to “Has a healthcare provider ever told you that you had a thyroid problem?” during follow-up interviews; control-patients were cohort members answering “No”. We used odds ratios (OR) with 95% confidence intervals (CI) to compare odds of thyroid disease by PBB and PCB exposure and by various risk factors. Total cumulative thyroid disease incidence after 33 years was 13.9% among women and 2.6% among men. After adjusting for body mass index, we found no statistically significant differences in odds of any type of thyroid disease among women or men with elevated PBB or PCB exposure. Compared to control-patients, women with thyroid disease had increased odds of being overweight/obese (OR = 2.82, 95% CI: 1.94-4.11) and developing infertility (OR = 1.71, 95% CI: 1.08-2.69), diabetes (OR = 1.61, 95% CI: 1.04-2.51), or arthritis (OR = 1.71, 95% CI: 1.18-2.50) during follow-up. Additional research should explore potential associations between PBBs/PCBs and thyroid disease among children exposed in utero. 相似文献
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介绍了一种新型汽封在国产600 MW机组节能改造中的应用。改造方案为将汽轮机组原通流部分及轴端的梳齿型汽封改为新型接触式密封齿+蜂窝汽封+铁素体齿的组合汽封,改造后漏汽量大幅减少,高、中、低压缸效率和机组运行的经济性明显提高,对同类型汽轮机通流部分节能改造具有较好的借鉴意义。 相似文献
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The objective of this exposure assessment was to reconstruct cumulative historical exposures for workers who have been exposed to multiple chemicals and chemical groups to better understand a cluster of brain cancers within a research and development lab. Chemicals of interest, including acrylates, bis-chloromethyl ether (BCME), chloromethyl methyl ether (CMME), isothiazolones and nitrosoamines, were selected on the basis of the plausibility of penetrating the blood-brain barrier and the uniqueness of the chemical's biological activity.In a complicated exposure setting such as a chemical R&D facility, multiple exposure estimation methods were needed. First, similarly exposure groups (SEGs) were created for these materials based on department group, time period of the department's existence and function associated with job titles. A probabilistic framework for assessing exposures was developed using Bayesian analysis of historical monitoring data, mathematical exposure modeling and professional judgments of current and former industrial hygienists at the facility were used to reconstruct the exposure history for acrylates, BCME and CMME for each SEG over the time period of interest. Since sufficient measurement data for isothiazolones and nitrosoamines were not available, the exposure histories for each SEG for these chemicals were estimated. This was done using objective formaldehyde levels and subjective employee interviews. The interviews assessed workplace determinants of exposure as distinct surrogates for estimating inhalation and dermal exposures. The exposure assessments by these methods were compared against each other to estimate the potential for exposure misclassification. A job exposure matrix (JEM) was constructed that contained the exposures obtained from above multiple approaches for each of these chemical groups for each SEG for each year of interest. The combination of methods used in this work is a unique and potentially helpful framework that can be used in analogous workplace settings involving multiple exposures with incomplete objective measurement information. 相似文献
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城市废弃工矿区土地再利用研究 总被引:1,自引:0,他引:1
加快城市废弃工矿区土地再利用,已成为发展矿区循环经济、提高城市土地利用效率有效途径之一。在对城市废弃工矿区土地再利用的相关概念界定的基础上.对城市废弃工矿区土地再利用理论和技术进行了综述,并提出存在的问题及建议。 相似文献
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水是西北地区生态系统重建的根本 总被引:24,自引:1,他引:24
我国以植树造林为核心的生态环境建设取得了很大成绩,到1997年全国已累计造林4627万hm2,其中“三北地区”3024万hm2。但也存在着很大问题,主要表现在平均造林成活率仅25%,保存率仅13%。经分析,西北地区少雨干旱,缺土壤水是“年年造林不见林”的主要原因。分析表明,水是西北地区生态系统重建的根本,而跨流域调水、加强水资源管理、雨水资源化、发展节水农业、普及节水意识等,是解决西北地区水资源短缺的根本途径。 相似文献