吉林省农业病虫害发生规律与防治效果的定量分析

本文以定量分析为主要手段，详细研究了吉林省农业病虫害发生的时间过程规律和空间分布规律，深入探讨了环境因子对农业病虫害的影响，综合评价了病虫害防治工作的效果。     

Water supply and sanitation services for all: global progress during the 1990s

The Earth may be largely covered with water, but over one billion people are estimated to be without safe drinking water and almost 2.5 billion (40% of the world's population) without adequate sanitation at the outset of the new millennium. The provision of safe water and sanitation for all poses several serious institutional and economic challenges at international, national and local levels. Despite the various political commitments made from the late 1970s onwards, these commitments have remained largely unfulfilled. Even though some efforts to expand coverage have been made over the past two decades, much of those efforts have been undermined by socioeconomic problems and growing population, particularly in the urban areas of developing countries. The water supply and sanitation sector is actually in acute need of new investments for expansion and maintenance of facilities. Nonetheless, some positive trends can be discerned, such as, for example, the increasing recognition of integrated water resources management, environmental sanitation, public-private partnerships and women as a key for improvement and expansion of services.     

1900个乡镇工业的工伤职业病医疗保障现状分析

在调查的１９００个乡镇工业企业中,有９．３％ 的企业对职工工伤职业病没有任何保障,其中尤其是个体联户所办企业则高达１５％ 。按行业进行分析,最易发生工伤职业病的各种矿山采选业、建材生产业,能给予报销医疗费的企业占７８．５％ ,部分给予报销的企业占１０．２％ ,不予报销企业占１１．３％ 。从保障程度看,能给予全部报销医疗费的企业仍以乡办企业为最高（９３．２％ ）,其次为村办企业（９０．２％ ）和个体联户所办企业（８８．５％ ）     

现代生物力学在煤矿安全科技中的应用研究

笔者根据国内外现代生物力学的发展情况 ,结合我国煤矿安全的现状 ,探讨现代生物力学在煤矿安全方面的应用 ,并提出了现代生物力学在安全科技两个方面的应用 :①研究人体结构在冲击事故的破坏极限 ,对安全帽的防护性能做简略的生物力学分析 ;②骨力———电性质的研究对骨折愈合与康复的意义。笔者提出随着现代科学技术的迅猛发展 ,煤矿安全方面的研究能否从现代生物力学在人体安全保护、骨折治疗与康复、职业病防治机理等方面的应用去研究的新思想和新方法 ,使煤矿安全的研究达到一个新的水平。     

Food and hunger in Sub-Saharan Africa

Sub-Saharan Africa is by far and away the most disadvantaged of the world's three main developing regions. Worse, its situation has mostly been deteriorating for much of the past several decades. Its agriculture is severely under-productive, and per capita food supplies have been steadily dwindling. Its environments and natural-resource base, characterised by water deficits, soil erosion, fuelwood shortages, rudimentary agro-practices, and grossly inadequate infrastructure, are generally unfavourable for sustainable agriculture. The population has expanded until it far exceeds carrying capacity, yet its growth rate is the highest in the world. The region also suffers from more disease than any other region. There is widespread and deepening poverty. As a result of these and other problems, and despite major food imports, two-thirds of the people are malnourished, one-quarter of whom endure outright hunger, even semi-starvation. Both these proportions appear set to keep on increasing both relatively and absolutely. Were these problems to persist with their decades-long trends, there could eventually arrive a stage when much larger numbers of people would succumb to terminal malnutrition, precipitating a human tragedy of unprecedented proportions. Fortunately, success stories demonstrate that solutions are available, on the part of both governments concerned and international agencies. Because of ignorance, or rather ignore-ance of the potential mortality disaster ahead, however, not nearly enough has been done to address the challenge with the energy and urgency to match its scale.     

IKK inhibition prevents PM2.5-exacerbated cardiac injury in mice with type 2 diabetes

Epidemiological studies have found that individuals with diabetes mellitus(DM) display an increased susceptibility for adverse cardiovascular outcomes when exposed to air pollution.This study was conducted to explore the potential mechanism linking ambient fine particles(PM2.5) and heart injury in a Type 2 DM(T2DM) animal model. The KKay mouse, an animal model of T2DM, was exposed to concentrated ambient PM2.5 or filtered air for 8 weeks via a versatile aerosol exposure and concentrator system. Simultaneously, an inhibitor of IκB kinase-2(IKK-a)(IMD-0354), which is a blocker of nuclear factor κB(NF-κB)nuclear translocation, was administrated by intracerebroventricular injection(ICV) to regulate the NF-êB pathway. The results showed that ambient PM2.5 induced the increase of, NF-êB, cyclooxygenase-2(COX-2) and mitogen activated protein kinase(MAPK) expression in cardiac tissue, and that IMD-0354 could alleviate the inflammatory injury. The results suggested that the NF-êB pathway plays an important role in mediating the PM2.5-induced cardiovascular injury in the T2DM model. Inhibiting NFκB may be a therapeutic option in air-pollution-exacerbated cardiovascular injury in diabetes mellitus.     

Prenatal exclusion of Leigh syndrome due to T8993C mutation in the mitochondrial DNA

Leigh syndrome (LS) is a mitochondrial encephalopathy that is caused by a mutation either in the mitochondrial DNA (mtDNA) or in the nuclear encoded genes of the mitochondrial proteins. Prenatal diagnosis of defects in the mtDNA is usually problematic because of mtDNA heteroplasmy and tissue specificity. However, the mutations T8993 G/C in the ATP synthase subunit 6 gene of the mtDNA show a more even tissue distribution and do not appear to change significantly over time. There are only few reports of prenatal diagnosis of the T8993G mutation in Leigh disease. Here we describe the first prenatal genetic testing of T8993C in a fetus of a mother whose previous child had died of Leigh syndrome due to the T8993C mutation. Mutant load in the chorionic villus sample (CVS) as well as in amniocytes was undetectable, thus predicting a very high likelihood of an unaffected outcome, indicative of a healthy baby. The diagnosis was confirmed after birth. Gathering data on the prenatal diagnosis of mtDNA mutations is of great importance so that prenatal diagnosis of both T8993G and T8993C mutations can be offered routinely. Copyright © 2002 John Wiley & Sons, Ltd.