单壁碳纳米管致昆明小鼠脑组织的氧化损伤

单壁碳纳米管(single walled carbon nanotubes,SWCNTs)是纳米材料研究关注的焦点之一.尽管如此,关于其神经毒性的研究相对较少.本研究将SWCNTs以不同的浓度(0 mg·kg-1·d-1,3.125 mg·kg-1·d-1,6.25 mg·kg-1·d-1,12.5 mg·kg-1·d-1),通过腹腔注射于Kunming小鼠体内.神经行为学实验(旷场实验)结果表明,在一定浓度的SWCNTs作用下,小鼠的情绪受到一定的影响,具有抑郁症的特征,出现移动能力下降,紧张等现象.同时小鼠脑部组织的活性氧族(reactive oxygen species,ROS)和丙二醛(malondialdehyde,MDA)水平升高(p0.05),还原型谷胱甘肽(glutathione,GSH)水平降低(p0.05),炎症因子白介素-1β(interleukin-1 beta,IL-1β)的水平升高(p0.05).组织学观察显示,随着染毒浓度的升高,脑海马锥体细胞的空泡化程度愈加明显,着色不均,锥体细胞顶状树突逐渐消失,细胞排列松散,尼氏小体消失.结论:一定浓度的SWCNTs可以导致小鼠脑组织发生病变,产生一定的神经毒性.     

Multiple biomarkers response in maize (Zea mays L.) during exposure to copper

Biomarkers in higher plants played an important role to estimate exposure effects of pollutants in soil ecosystem and have received increasing attention in recent years. The qualitative and quantitative modifications arising in amplified fragment length polymorphism （AFLP） profiles as a measure of DNA effects were compared with a number of parameters, namely, the root length, total soluble protein content in root tips, chlorophylls content and shoot size to select the most sensitive biomarker responding to copper stress in the range of 0--600 mg/kg. The changes occurring in AFLP profiles of root tips following Cu treatment included loss of normal bands and appearance of new bands and variation in band intensity in comparison to that of the normal seedlings, A reduction in root length was observed at the 200 mg/kg of copper, which was accompanied with a decrease in total soluble protein content. According to their sensitivity to the copper toxicity, the above indicator rank in the following order： AFLP profiles 〉 total soluble protein content 〉 root length 〉 chlorophylls content 〉 shoot. We concluded that the AFLP offered a useful alternative hiomarker assay for the detection of genotoxic effects of environmental pollutants.     

Do nanoparticles present ecotoxicological risks for the health of the aquatic environment?

Nanotechnology is a major innovative scientific and economic growth area, which may present a variety of hazards for environmental and human health. The surface properties and very small size of nanoparticles and nanotubes provide surfaces that may bind and transport toxic chemical pollutants, as well as possibly being toxic in their own right by generating reactive radicals. There is a wealth of evidence for the harmful effects of nanoscale combustion-derived particulates (ultrafines), which when inhaled can cause a number of pulmonary pathologies in mammals and humans. However, release of manufactured nanoparticles into the aquatic environment is largely an unknown. This review addresses the possible hazards associated with nanomaterials and harmful effects that may result from exposure of aquatic animals to nanoparticles. Possible nanoparticle association with naturally occurring colloids and particles is considered together with how this could affect their bioavailability and uptake into cells and organisms. Uptake by endocytotic routes are identified as probable major mechanisms of entry into cells; potentially leading to various types of toxic cell injury. The higher level consequences for damage to animal health, ecological risk and possible food chain risks for humans are also considered based on known behaviours and toxicities for inhaled and ingested nanoparticles in the terrestrial environment. It is concluded that a precautionary approach is required with individual evaluation of new nanomaterials for risk to the health of the environment. Although current toxicity testing protocols should be generally applicable to identify harmful effects associated with nanoparticles, research into new methods is required to address the special properties of nanomaterials.     

环境损害的法律定义研究

结合近年发生的重大环境污染与破坏事故,从环境权益的角度,深入剖析“环境损害”的现象与实质,兼与“环境侵权”、“环境侵害”辨析,借鉴国外立法经验,为制定我国《环境损害赔偿法》界定“环境损害”的法律定义。     

深圳市某采石场边坡稳定性评价及支护建议

随着深圳特区经济建设的快速发展,所需建筑石材日益增长,而开山挖石留下的大量边坡对附近建(构)筑物形成了较大的安全隐患。本文以深圳某采石场边坡工程为实例,详细地分析了该边坡的稳定性,对类似工程问题的评价、治理有一定的实际意义。     

包头6.4级地震多层砖房震害与分析

人们对于如何抗御地震灾害的认识,在很大程度上来自地震的经验,本文根据现场调查的结果,对包头地震中多层砖房的震害进行了统计,对不同设防情形的多层砖房震害进行了比较;还选取５栋多层砖房进行了抗震验算,并与其实际震害进行了对比分析。     

PROBLEMS OF REESTABLISHING COMMERCIAL RECREATION BUSINESSES IN NEW YORK FOLLOWING HURRICANE AGNES1

ABSTRACT: Forty-two commercial campgrounds and 34 commercial marinas were studied to determine the amount and types of flood-related damages incurred from Hurricane Agnes, and to evaluate the institutional measures available to help management overcome these losses. Economic losses incurred by firms due to inability to operate, and declines in the number of recreationists, were over twice the magnitude of losses suffered via direct physical damages from flooding. The Federal Flood Insurance Program, as presently constituted, is of very little use to firms having structural investments in and over water. Most firms were complimentary of the Small Business Administration's loan programs. It appears that active programs of communication and promotion are needed following restoration of regions involved in natural diasters to reestablish the tourist industry of those regions.     

旅游资源的开发与环境保护

随着旅游业的发展,旅游资源的开发,环境资源也遭到了严重破坏,本文从旅游资源开 发对环境和旅游资源的影响入手,提出了开发旅游资源的风景保护对策。     

警惕生态旅游中的"生态破坏"

生态旅游是当今世界旅游业的一个热点，受到人们的普遍关注。但是由于人们对生态旅游的认识存在偏差，以及盲目地追求经济效益，使生态旅游演变成了破坏生态的旅游。本文讨论了生态旅游的内涵，提出了目前生态旅游中存在的问题，并提出了实现生态旅游可持续发展的若干建议。