The modern theory of biological evolution: an expanded synthesis

In 1858, two naturalists, Charles Darwin and Alfred Russel Wallace, independently proposed natural selection as the basic mechanism responsible for the origin of new phenotypic variants and, ultimately, new species. A large body of evidence for this hypothesis was published in Darwins Origin of Species one year later, the appearance of which provoked other leading scientists like August Weismann to adopt and amplify Darwins perspective. Weismanns neo-Darwinian theory of evolution was further elaborated, most notably in a series of books by Theodosius Dobzhansky, Ernst Mayr, Julian Huxley and others. In this article we first summarize the history of life on Earth and provide recent evidence demonstrating that Darwins dilemma (the apparent missing Precambrian record of life) has been resolved. Next, the historical development and structure of the modern synthesis is described within the context of the following topics: paleobiology and rates of evolution, mass extinctions and species selection, macroevolution and punctuated equilibrium, sexual reproduction and recombination, sexual selection and altruism, endosymbiosis and eukaryotic cell evolution, evolutionary developmental biology, phenotypic plasticity, epigenetic inheritance and molecular evolution, experimental bacterial evolution, and computer simulations (in silico evolution of digital organisms). In addition, we discuss the expansion of the modern synthesis, embracing all branches of scientific disciplines. It is concluded that the basic tenets of the synthetic theory have survived, but in modified form. These sub-theories require continued elaboration, particularly in light of molecular biology, to answer open-ended questions concerning the mechanisms of evolution in all five kingdoms of life.Dedicated to Prof. Dr. Dr. hc mult. Ernst Mayr on the occasion of his 100th birthdayThis revised version was published online in March 2004, with corrections to the caption of Figure 6.     

Besteht die Möglichkeit zur Übertragung von AIDS durch blutsaugende Insekten?

The question whether the possibility exists of transmission of HIV by hematophagous insects from infected to uninfected persons is a point of very intensive discussion. The solution of this problem could help to explain the spreading of the disease in human populations and could contribute to an understanding of the evolution of AIDS and the possible transfer from wild primates into human populations. The classical routes of pathogen transmission by blood-sucking arthropods are either "mechanical" or "biological". Both ways are rejected, the latter since no replication of the retro-virus in the vector exists and its survival in the arthropod is very limited. Based on long experimental experience with biting flies as well as with plant-sucking insects a third hitherto neglected way of transmission by regurgitation of gut content can be introduced. Since regurgitation is neither "mechanical" nor "biological", "regurgitative transmission" must be introduced as an additional term.