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Methods for life cycle assessment of products (LCA) are most often based on the general prevention principle, as opposed to the risk minimization principle. Here, the desirability and feasibility of a combined approach are discussed, along with the conditions for elaboration in the framework of LCA methodology, and the consequences for LCA practice. A combined approach provides a separate assessment of above and below threshold pollution, offering the possibility to combat above threshold impacts with priority. Spatial differentiation in fate, exposure, and effect modelling is identified to play a central role in the implementation. The collection of region-specific data turns out to be the most elaborate requirement for the implementation in both methodology and practice. A methodological framework for the construction of characterization factors is provided. Along with spatial differentiation of existing parameters, two newly introduced spatial parameters play a key role: the sensitivity factor and the threshold factor. The practicability of the proposed procedure is illustrated by an example of its application. Providing a reasonable data availability, the development of separate LCA characterization factors for the respective assessment of pollution levels above and below environmental threshold values seems to be a feasible task that may add to LCA credibility.  相似文献   
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We tested joint effects of predator loss and increased resource availability on the grazers’ trophic level and the propagation of trophic interactions in a benthic food web by excluding larger predatory fish from cages and manipulating nutrients in the coastal zone of the Baltic Sea. The combination of nutrient enrichment and excluding larger predators induced an increase in medium-sized predatory fish (three-spined stickleback). The meso-predator fish in turn did not change the total abundance of the invertebrate herbivores, but did cause a substantial shift in their community composition towards the dominance of gastropods by reducing amphipods by 40–60%, while gastropods were left unchanged. The shift in grazer composition generated a 23 times higher producer biomass, but only under nutrient enrichment. Our results show that top-predator declines can substantially shift the species composition at the grazers’ level, but that cascading effects on producers by a trophic cascade strongly depend on resource availability.  相似文献   
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Feed spacers in spiral-wound reverse osmosis membrane modules are highly susceptible to deposition or attachment of suspended particulates and organic matters in the feed stream. This type of fouling can cause a significant pressure drop along the membrane channel (differential pressure) without much effect on the average permeate flux. In practical applications, membrane cleaning is often triggered when the differential pressure in a membrane channel exceeds a threshold value. A mathematical model was developed to simulate the development of differential pressure in the feed channel resulting from foulant capture by the feed spacers. Simulations were carried out to investigate and demonstrate the effect of various parameters on differential pressures in the membrane channel. Differential pressures observed in a two-stage reverse osmosis water reclamation plant were simulated with the model, and the results showed that the model could adequately describe the increase of differential pressure with operating time in the reverse osmosis plant.  相似文献   
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The interaction of chemicals with biological organisms is as old as life itself. Chemical pollution is usually considered to be human interference with natural chemical cycles and the release of man-made, unnatural compounds. The article traces five areas of chemical pollution and health hazards: air pollution, water pollution, occupational exposure, pollution from agricultural practices and contamination of food. It is suggested that historic perspective can aid in rational and prudent evaluation of present-day pollution problems.  相似文献   
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The Holt-Oram syndrome is an autosomal dominant disorder consisting of a congenital heart defect in combination with characteristic upper limb abnormalities. This report presents the ultrasonographic follow-up of two fetuses at risk for the Holt-Oram syndrome. In the first fetus, the existence of Holt-Oram syndrome was suspected at 22 weeks of gestation; a ventricular septal defect, an atrial septal defect, and a minor skeletal defect were found. In the second fetus, no structural abnormalities were discovered until the 30th week, when a small atrial septal defect was detected. In both pregnancies, it was possible to exclude early in gestation the more severe forms of the Holt-Oram syndrome.  相似文献   
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In a marine ecosystem, the diversity of phytoplankton can influence the diversity of zooplankton, or vice versa, and both can be affected by the environmental factors. In this study, we used principal component analysis (PCA) to identify the major sources of influence on the coastal water near an industrial park, following by construction of structural equation model (SEM) to determine the direct and indirect effect of the factors on phytoplankton and zooplankton diversity. PCA results indicated that the coastal area was mainly affected by riverine discharge (represented by high PC factor loadings of transparency and turbidity) and seasonal change (represented by temperature). SEM further suggested that both riverine discharge and seasonal influences can directly affect phytoplankton diversity, but indirectly affected zooplankton diversity via changes in phytoplankton. Using PCA to determine the sources of influence followed by construction of SEM allowed us to understand the relative importance of the environmental factors, direct or indirect, on phytoplankton and zooplankton diversity. When environmental changes occur, a new SEM could be constructed using the same category of physical and biological data and then compared to the current model to verify whether the environmental changes were the cause of alterations in planktonic communities in the area.  相似文献   
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