Maternal serum inhibin levels in second-trimester down's syndrome pregnancies

Maternal serum inhibin levels were measured in 19 second-trimester pregnancies affected by fetal Down's syndrome and 95 unaffected control pregnancies matched for gestational age. A statistically significant elevation was found in the affected pregnancies compared with the controls (Wilcoxon rank sum test: one-tail P=0·02). The median level in the cases was 1·3 times that in the controls, with 95 per cent confidence limits of 0·9–1·9. Although the inhibin levels were unrelated to those of alpha-fetoprotein and unconjugated oestriol in the same samples, there was a statistically significant correlation with human chorionic gonadotropin. This together with the relatively small elevation in cases suggests that inhibin would be of limited value in maternal serum screening for Down's syndrome.     

Tipping Elements in the Arctic Marine Ecosystem

The Arctic marine ecosystem contains multiple elements that present alternative states. The most obvious of which is an Arctic Ocean largely covered by an ice sheet in summer versus one largely devoid of such cover. Ecosystems under pressure typically shift between such alternative states in an abrupt, rather than smooth manner, with the level of forcing required for shifting this status termed threshold or tipping point. Loss of Arctic ice due to anthropogenic climate change is accelerating, with the extent of Arctic sea ice displaying increased variance at present, a leading indicator of the proximity of a possible tipping point. Reduced ice extent is expected, in turn, to trigger a number of additional tipping elements, physical, chemical, and biological, in motion, with potentially large impacts on the Arctic marine ecosystem.     

The relationship between epilithic periphyton (biofilm) bound metals and metals bound to sediments in freshwater systems

Surficial sediments and epilithic periphyton (biofilm) were sampled from six sites on the River Churnet and five sites on the River Manifold in Staffordshire and analysed for cadmium (Cd), copper (Cu), lead (Pb) and zinc (Zn). The sites demonstrated a wide range of sediment trace metal concentrations determined by inductively coupled plasma optical emission spectrometry (ICP-OES) and atomic absorbtion spectroscopy (AAS). Biofilm was removed from the substrate using physical abrasion and 0.005 M ethylenediaminoethanetetra-acetic acid (EDTA) extractant. The European Standards, Measurements and Testing Programmes (BCR) operationally defined geochemical speciation scheme was used to determine the exchangeable, acid soluble fraction of the sediments. Significant positive correlations were determined between the EDTA extractable biofilm and the exchangeable sediment fraction for Cd, Cu and Zn but not for Pb. Natural epilithic periphyton may be a potential metal biomonitor particularly of Cu, Cd and Zn in aquatic systems and provide supporting information in relation to potential sediment toxicity.     

Risk to water security for small islands: an assessment framework and application

The freshwater resources of small islands are particularly vulnerable to the impacts of climate change and human stressors due to their limited extent and adaptive capacity. A water security approach is useful for effective management of the water resources; however, understanding risk to water security is critical in order to effectively plan and adapt to future changes. Currently available assessment tools generally do not incorporate risk and are not suitable for application on small islands, where the hydrogeological setting has unique vulnerabilities. The aim of this work is to provide a framework to characterize risk to water security for small islands. The risk assessment was developed using Andros Island, the Bahamas, as a case study area. Numerical modelling characterizes the response of the water system to potential future stressors related to climate change and human development, the results of which are integrated into the assessment framework. Based on risk assessment principles, indicators are determined for susceptibility, hazard threat, vulnerability and loss, in order to define the risk to water security. The resulting indicators are presented in geospatial maps that rank areas of risk to water security. These maps were provided to local water managers and policy-makers in the Bahamas as a tool to identify high-risk areas for near-term action and to inform long-term planning. The maps have also been used as a platform to engage local residents and raise awareness about the impact climate change and land-use activities may have on water security.