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The mutagenic and carcinogenic effects of parathion-methyl were examined by bacterial reverse assay and a long term experiment with Wistar rats. The potential mutagenic effect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas of the rats. The results from short-term Ames test and long-term rat experiments suggest that parathion-methyl would be potential carcinogenic. 相似文献
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Ara Talat Nisa Waqar-Un Aziz Rukhsanda Rafiq Muhammad Tariq Gill Rafaqat Ali Hayat Malik Tahir Afridi Uzma 《Environmental geochemistry and health》2021,43(10):4345-4345
Environmental Geochemistry and Health - A correction to this paper has been published: https://doi.org/10.1007/s10653-021-00910-5 相似文献
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Ara Talat Nisa Waqar-Un Aziz Rukhsanda Rafiq Muhammad Tariq Gill Rafaqat Ali Hayat Malik Tahir Afridi Uzma 《Environmental geochemistry and health》2021,43(9):1-11
Environmental Geochemistry and Health - As the largest organ of the human body, the skin is the major exposure route of NO2. However, the evidence for a relationship between NO2 exposure and... 相似文献
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M. Nisa Unaldi Coral Sonay Ucman Hasan Yildiz Haydar Oztas Semih Dalkilic 《环境科学学报(英文版)》2009,21(5):696-699
The mutagenic and carcinogenic e ects of parathion-methyl were examined by bacterial reverse mutation assay and a long-term
experiment with wistar rats. The potential mutagenic e ect of parathion-methyl in Salmonella typhimurium TA100 bacterial cells was
observed without rat liver S9 metabolic activation. Parathion-methyl was further investigated for pathological changes in rat pancreas
and liver. The long-term rat experiments showed that parathion-methyl exposure for 3 months can cause pathological changes in rat
pancreases acinar cells and pancreatic hepatocytes. Atypical acinar cell focuses (AACF) were determined in the liver and pancreas
of the rats. The results from short-term Ames test and long-term rat experiments suggested that parathion-methyl would be potential
carcinogenic. 相似文献
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