环境中的药物——LC-MS/MS分析地表水和地下水

成百上千的活性物质正被用于人药和兽药处方中.由于药物的广泛应用,它们的残留物可通过多种途径进入环境.虽然主要通过尿和粪便的排泄,但是药品生产中的排放也应被考虑.当抗生素用于水产业,就会产生更直接的影响.污水处理设备不能完全除去药物,因此药物会出现在地表和地下水样品中.近年来,人们对环境中药物的兴趣正在增加,需要建立一种快速、灵敏、有选择性的方法来分析水样.     

Urban geochemistry: research strategies to assist risk assessment and remediation of brownfield sites in urban areas

Urban geochemical maps of Wolverhampton and Nottingham, based on multielement analysis of surface soils, have shown distribution patterns of “total” metals concentrations relating to past and present industrial and domestic land use and transport systems. Several methods have been used to estimate the solubility and potential bioavailability of metals, their mineral forms and potential risks to urban population groups. These include sequential chemical extraction, soil pore water extraction and analysis, mineralogical analysis by scanning electron microscopy, source apportionment by lead isotope analysis and the development of models to predict metal uptake by homegrown vegetables to provide an estimate of risk from metal consumption and exposure. The results from these research strategies have been integrated with a geographical information system (GIS) to provide data for future land-use planning.     

Assessment of the Extreme Rainfall Event at Nashville,TN and the Surrounding Region on May 1–3, 2010

This paper analyzes the May 1–3, 2010 rainfall event that affected the south‐central United States, including parts of Mississippi, Tennessee, and Kentucky. The storm is evaluated in terms of its synoptic setting, along with the temporal distributions, and spatial patterns of the rainfall. In addition, the recurrence interval of the storm is assessed and the implications for hydrologic structure designs are discussed. The event was associated with an upper‐level trough and stationary frontal boundary to the west of the rainfall region, which remained quasi‐stationary for a period of 48 h. Heavy rainfall was produced by two slow‐moving mesoscale convective complexes, combined with abundant atmospheric moisture. Storm totals exceeding 330 mm occurred within a large elongated area extending from Memphis to Nashville. Isolated rainfall totals over 480 mm were reported in some areas, with NEXRAD weather radar rainfall estimates up to 501 mm. An extreme value analysis was performed for one‐ and two‐day rainfall totals at Nashville and Brownsville, Tennessee, as well as for gridded rainfall estimates for the entire region using the Storm Precipitation Analysis System. Results suggest maximum rainfall totals for some durations during the May 1–3, 2010 event exceeded the 1,000‐year rainfall values from National Oceanic and Atmospheric Administration Atlas 14 for a large portion of the region and reached up to 80% of the probable maximum precipitation values for some area sizes and durations.     

Microscopic and chemical studies of metal particulates in tree bark and attic dust: evidence for historical atmospheric smelter emissions, Humberside, UK

Tree barks and attic dusts were examined as historical archives of smelter emissions, with the aim of elucidating the pathways of pollution associated with a plume of Sn and Pb contamination in top soils, found close to the former Capper Pass smelter, Humberside, UK. Samples were collected from three villages within the area of the contamination plume. Scanning electron microscopy (SEM) and bulk chemical analyses were used to assess particle type, number and deposition patterns. SEM analysis of dusts and bark revealed that Sn and Pb particles were present in samples from all three villages along with copper, zinc and iron particles. These were almost entirely <10 microm in diameter and occurred mostly as oxides, frequently forming clusters of sub-micron crystals. Samples further from the smelter contained considerably fewer particles. We present images of smelter derived Sn particles. Chemical assays of the barks and attic dusts demonstrated that concentrations of Sn, Pb, Cu, As, Sb and Cd diminished with increasing distance from the source. Strong positive correlations were found between Sn and Pb, As, Sb and Cd in the attic dusts. Enrichment factors (EF) were calculated for these trace elements based on topsoil element concentrations obtained from the soil survey of the study area. Decreases in these trace element concentrations and EF values with distance away from the smelter are consistent with trends found in the soil survey for Sn and Pb and are typical of deposition patterns around smelter stacks. The study demonstrates that tree bark and attic dusts can be effective archives of metal particulates deposited from large static emission sources.     

Crop uptake of heavy metals in response to the environment and agronomic practices on land near mine tailings in the Zambian Copperbelt Province

Environmental Geochemistry and Health - A field experiment was undertaken on farmers’ fields adjacent to a large mine tailings dam in the Zambian mining town of Kitwe. Experimental plots were...     

Cross-sectional biomonitoring study of pesticide exposures in Queensland,Australia, using pooled urine samples

A range of pesticides are available in Australia for use in agricultural and domestic settings to control pests, including organophosphate and pyrethroid insecticides, herbicides, and insect repellents, such as N,N-diethyl-meta-toluamide (DEET). The aim of this study was to provide a cost-effective preliminary assessment of background exposure to a range of pesticides among a convenience sample of Australian residents. De-identified urine specimens stratified by age and sex were obtained from a community-based pathology laboratory and pooled (n = 24 pools of 100 specimens). Concentrations of urinary pesticide biomarkers were quantified using solid-phase extraction coupled with isotope dilution high-performance liquid chromatography–tandem mass spectrometry. Geometric mean biomarker concentrations ranged from <0.1 to 36.8 ng/mL for organophosphate insecticides, <0.1 to 5.5 ng/mL for pyrethroid insecticides, and <0.1 to 8.51 ng/mL for all other biomarkers with the exception of the DEET metabolite 3-diethylcarbamoyl benzoic acid (4.23 to 850 ng/mL). We observed no association between age and concentration for most biomarkers measured but noted a “U-shaped” trend for five organophosphate metabolites, with the highest concentrations observed in the youngest and oldest age strata, perhaps related to age-specific differences in behavior or physiology. The fact that concentrations of specific and non-specific metabolites of the organophosphate insecticide chlorpyrifos were higher than reported in USA and Canada may relate to differences in registered applications among countries. Additional biomonitoring programs of the general population and focusing on vulnerable populations would improve the exposure assessment and the monitoring of temporal exposure trends as usage patterns of pesticide products in Australia change over time.     

Microeconomic measurement of the social costs of environmental regulation

This paper provides a coherent microeconomic framework for defining and measuring the social costs of environmental regulations. A fundamental identity between two alternative means of measuring social costs is established and used to illustrate how erroneous methodologies have crept into the impact assessment literature. Several interesting cases of “ripple effects” including those related to the siting of hazardous waste disposal facilities are considered using this identity.