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Coppi Andrea Colzi Ilaria Lastrucci Lorenzo Castellani Maria Beatrice Gonnelli Cristina 《Environmental science and pollution research international》2022,29(35):52752-52760
Environmental Science and Pollution Research - In this work, we evaluated whether the species Myriophyllum aquaticum (Vell.) Verdc. can be a promising material for devising reliable... 相似文献
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Helen Carnaghan Catherine P. James Paul B. Charlesworth Marco Ghionzoli Susana Pereira Mohamed Elkhouli David Baud Paolo De Coppi Greg Ryan Prakesh S. Shah Mark Davenport Anna L. David Agostino Pierro Simon Eaton Gastroschisis Study Group 《黑龙江环境通报》2020,40(8):991-997
Objective
In gastroschisis, there is evidence to suggest that gut dysfunction develops secondary to bowel inflammation; we aimed to evaluate the effect of maternal antenatal corticosteroids administered for obstetric reasons on time to full enteral feeds in a multicenter cohort study of gastroschisis infants.Methods
A three center, retrospective cohort study (1992-2013) with linked fetal/neonatal gastroschisis data was conducted. The primary outcome measure was time to full enteral feeds (a surrogate measure for bowel function) and secondary outcome measure was length of hospital stay. Analysis included Mann-Whitney and Cox regression.Results
Of 500 patients included in the study, 69 (GA at birth 34 [25-38] weeks) received antenatal corticosteroids and 431 (GA at birth 37 [31-41] weeks) did not. Antenatal corticosteroids had no effect on the rate of reaching full feeds (Hazard ratio HR 1.0 [95% CI: 0.8-1.4]). However, complex gastroschisis (HR 0.3 [95% CI: 0.2-0.4]) was associated with an increased time to reach full feeds and later GA at birth (HR 1.1 per week increase in GA [95% CI: 1.1-1.2]) was associated with a decreased time to reach full feeds.Conclusion
Maternal antenatal corticosteroids use, under current antenatal steroid protocols, in gastroschisis is not associated with an improvement in neonatal outcomes such as time to full enteral feeds or length of hospital stay. 相似文献
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