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排序方式: 共有101条查询结果,搜索用时 15 毫秒
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Frans J. Los MD PhD Diane Van Opstal Martin P. Schol Johannes L. J. Gaillard Helen Brandenburg Ans M. W. Van Den Ouweland Peter A. In 'T Veld 《黑龙江环境通报》1995,15(12):1155-1159
A prenatally detected case of a rare mosaic tetrasomy 12p/trisomy 12p is reported, presenting as the well-known accessory isochromosome 12p and a supernumerary single 12p marker in 17/24 and 6/24 clones of cultured amniotic fluid cells, respectively. The chromosomal nature of both marker chromosomes was investigated in cultured amniotic fluid cells by fluorescent in situ hybridization with various probes: the 12-centromeric probes pa12H8 and D12Z3, a whole chromosome 12 paint, and the chromosome 12p-specific paint M28. DNA analysis revealed a maternal origin of the extra 12p material. After counselling, the parents requested termination of pregnancy. Inspection and autopsy of the fetus revealed many of the dysmorphisms and internal structural abnormalities of the Pallister–Killian syndrome. 相似文献
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Christine Willekes Frans J. M. E. Roumen MD PhD Anne-Marie W. van Elsacker-Niele Harro T. Weiland Christl Vermey-Keers Johan H. J. M. van Krieken Christine E. M. de Die-Smulders Guus J. H. Hamers Gerrie P. M. Vaes-Peters 《黑龙江环境通报》1994,14(3):181-185
In a case of hydrops fetalis, serological examination showed a recent maternal human parvovirus B19 infection. Amniocentesis revealed a unique unbalanced translocation between chromosomes 3 and 11 of the fetus. The mother proved to have a balanced reciprocal translocation between chromosomes 3 and 11. A grossly macerated hydropic male fetus was delivered with a flat nose and low implanted deformed ears. Histopathological examination revealed nuclear inclusion bodies in fetal erythroid cells, confirming human parvovirus B19 infection. Parvovirus B19 DNA was demonstrated by in situ hybridization in the nuclei of heart muscle cells. Our finding of two different disorders in one case illustrates the importance of a complete evaluation of every case of hydrops fetalis, especially concerning counselling on the outcome of future pregnancies. The human parvovirus B19 infection will not recur due to the acquired immunity of the mother, whereas the balanced reciprocal translocation will endanger future pregnancies. 相似文献
4.
Franck L. B. Meijboom Nina Cohen Elsbeth N. Stassen Frans W. A. Brom 《Journal of Agricultural and Environmental Ethics》2009,22(6):559-571
European animal disease policy seems to find its justification in a “harm to other” principle. Limiting the freedom of animal
keepers—e.g., by culling their animals—is justified by the aim to prevent harm, i.e., the spreading of the disease. The picture,
however, is more complicated. Both during the control of outbreaks and in the prevention of notifiable, animal diseases the
government is confronted with conflicting claims of stakeholders who anticipate running a risk to be harmed by each other, and who ask for government intervention. In this paper, we first argue that in a policy that
aims to prevent animal diseases, the focus shifts from limiting “harm” to weighing conflicting claims with respect to “risks
of harm.” Therefore, we claim that the harm principle is no longer a sufficient justification for governmental intervention
in animal disease prevention. A policy that has to deal with and distribute conflicting risks of harm needs additional value
assumptions that guide this process of assessment and distribution. We show that currently, policies are based on assumptions
that are mainly economic considerations. In order to show the limitations of these considerations, we use the interests and
position of keepers of backyard animals as an example. Based on the problems they faced during and after the recent outbreaks,
we defend the thesis that in order to develop a sustainable animal disease policy other than economic assumptions need to
be taken into account. 相似文献
5.
Nina E. Cohen Frans W. A. Brom Elsbeth N. Stassen 《Journal of Agricultural and Environmental Ethics》2009,22(4):341-359
In this paper, we present and defend the theoretical framework of an empirical model to describe people’s fundamental moral
attitudes (FMAs) to animals, the stratification of FMAs in society and the role of FMAs in judgment on the culling of healthy
animals in an animal disease epidemic. We used philosophical animal ethics theories to understand the moral basis of FMA convictions.
Moreover, these theories provide us with a moral language for communication between animal ethics, FMAs, and public debates.
We defend that FMA is a two-layered concept. The first layer consists of deeply felt convictions about animals. The second
layer consists of convictions derived from the first layer to serve as arguments in a debate on animal issues. In a debate,
the latter convictions are variable, depending on the animal issue in a specific context, time, and place. This variability
facilitates finding common ground in an animal issue between actors with opposing convictions. 相似文献
6.
Felix Deutsch Jean Vankerkom Liliane Janssen Filip Lefebre Clemens Mensink Frans Fierens Gerwin Dumont Edward Roekens 《Environmental Modeling and Assessment》2008,13(3):431-437
The European Operational Smog (EUROS) integrated air quality modelling system has been extended to model fine particulate
matter (PM). From an extended literature study, the Caltech Atmospheric Chemistry Mechanism and the Model of Aerosol Dynamics,
Reaction, Ionisation and Dissolution were selected and recently coupled to EUROS. Currently, modelling of mass and chemical
composition of aerosols in two size fractions (PM2.5 and PM10–2.5) is possible. The chemical composition is expressed in terms of seven components: ammonium, nitrate, sulphate, elementary
carbon, primary inorganic compounds, primary organic compounds and secondary organic compounds. Calculated PM10 concentrations and chemical composition are presented for two summer months of the year 2003 (1 July to 31 August). 相似文献
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无论从经济还是从自然保护角度,冲积平原和三角洲的社会压力都很大.随着经济的发展及大坝增高,由于预期的损失上升和更深的洪水,洪水风险在逐渐增加.全球变化,社会需求变化了,人们的观念也变化了,需要修订长期的洪水风险管理战略.而修订洪水风险管理战略应以柔性战略替代过去以加高大坝为主的刚性战略.柔性战略为主的洪水风险管理就意味着允许洪水临时性大面积泛滥,通过改变土地利用方式减少洪水灾害损失.这样的战略是基于风险管理和"与洪水共生存"的理念提出的,完全替代了过去的灾害控制观念.荷兰三角洲地区是世界人口密度最大区域之一,在这里,灵活的柔性洪水风险管理战略水文功能和"可持续的标准"被详细阐述和评估. 相似文献
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