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Afify Marwa Adel Ahmed Iman Gamal Ghareeb Alkahtani Theeb Ayedh Altulayhi Raed Ibrahim Alrowili Amjad Saud Mhrb Ghozy Sherief Bin-Jumah May Abdel-Daim Mohamed M. 《Environmental science and pollution research international》2021,28(9):10576-10588
Environmental Science and Pollution Research - This research aims to study the safety and efficacy of doravirine in the treatment of HIV-1 (human immunodeficiency virus) patients. We conducted an... 相似文献
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Hussien Hend M. Ghareeb Doaa A. Ahmed Hany E. A. Hafez Hani S. Saleh Samar R. 《Environmental science and pollution research international》2021,28(46):65349-65362
Environmental Science and Pollution Research - Long-term exposure to environmental neurotoxic metals is implicated in the induction of dementia and cognitive decline. The present study aims to... 相似文献
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Atya Marwa E. El-Hawiet Amr Alyeldeen Mohamed A. Ghareeb Doaa A. Abdel-Daim Mohamed M. El-Sadek Mohamed M. 《Environmental science and pollution research international》2021,28(16):19664-19676
Environmental Science and Pollution Research - Brown seaweeds are rich in polysaccharides, such as fucoidan (FUC) which has shown beneficial effects in several medical conditions. The aim of the... 相似文献
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Doaa A. Ghareeb Ashraf M. Elbassoumy Hend M. Hussien Marwa M. Abo-Sraiaa 《毒物与环境化学》2013,95(7):1357-1372
Acrylamide (ACR) exerts its toxicity through stimulation of the oxidative stress; yet, its effect on neurotransmitter catabolic enzymes has not been elucidated. We investigated the effects of ACR exposure on brain and hepatic tissues antioxidant enzymes activities and different markers such as, acetylcholinesterase (AChE), nitric oxide (NO), monoamine oxidase (MAO), and lipid profile, and to evaluate the protective effects of garlic against ACR toxicity. Male Sprague-Dawley rats were exposed to ACR (1 mg kg?1 body weight) with or without diet containing 1.5% of garlic powder for 40 days. ACR administration showed a decrease in AChE activity associated with an increase in MAO activity in both brain and hepatic tissues. In addition, ACR administration increased the lipid peroxidation and NO levels of both tissues while decreased the activities of glutathione (GSH), superoxide dismutase, and glutathione-S-transferase (GST). On the other hand, the activities of glutathione peroxidase (GPx) and catalase activities increased as a consequence of GSH depletion after ACR exposure. Finally, ACR exposure increased the brain and liver lipid profile of cholesterol, triglycerides and total lipid, while phospholipids level was decreased. Coadministration of garlic powder with ACR significantly attenuated oxidative stress, MAO activity, and inflammation in brain and hepatic tissues but did not ameliorate AChE activity. In conclusion, our results emphasized the role of garlic as a potential adjuvant therapy to prevent ACR neurotoxicity and hepatotoxicity. 相似文献
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