The first world conservation lecture

Summary This, The First World Conservation Lecture, was presented at the Royal Institution, London, UK, on 12 March 1981. The Lecture celebrated the 20th anniversary of the World Wildlife Fund, and the first anniversary of the World Conservation Strategy. The Lecture was organized by the World Wildlife Fund, UK.Published with the kind permission of the World Wildlife Fund, UK.Edward Max Nicholson, CB, CVO, Commandeur (Netherlands), Order of the Golden Ark, holds honorary doctorates from the University of Aberdeen, and The Royal College of Art London. He was educated at the University of Oxford, and was a member of the University's expeditions to Greenland (1928) and to British Guiana (1929). He was General Secretary (until 1940), later Chairman of PEP (Political and Economic Planning): now Vice-President of its successor body, the Policy Studies Institute. From 1945 to 1952 he was Secretary of the Office of the Lord President of the Council, then Deputy Prime Minister of the United Kingdom. He was member of the Advisory Council on Scientific Policy from 1948–1964. In 1952 he was leader of the joint UN/FAO Development Team in Baluchistan. Charter Member from 1949, and Director-General (1952–1966) of the Nature Conservancy, London, UK. From 1963 to 1974 he was Convenor of the Conservation Section of the International Council of Scientific Unions' International Biological Programme. President of the IUCN Technical Meeting in Edinburgh in 1956, concerned with rehabilitation of areas biologically devastated by human disturbance, and relation of ecology to landscape planning. Member, Panel on Landscape Action Program, The White House Conference (USA) on Natural Beauty (1965). Secretary, HRH The Duke of Edinburgh's Study Conference on The Countryside in 1970 (1963 and 1965). Council and Board Member of IIED. Godman-Salvin Medallist British Ornithologist Unions. Phillips Medallist and Member of Honour IUCN, Geoffroy St. Hilaire Gold Medal, Société Nationale de Protection de Nature de France, Premio Europeo Cortina-Ulisse (1971), Europa Preis für Landespflege (1972), Hon Member of World Wildlife Fund, Chairman Ecological Parks Trust, President RSPB, 1980. Principal Consultant and Chairman of Land Use Consultants Ltd (London) since 1966. Author of many books,Birds and Men (1951);Britain's Nature Reserves (1958),The System (1967);The Environmental Revolution (1970).     

Degradation of macrolide antibiotics by ozone: a mechanistic case study with clarithromycin

Macrolide antibiotics are widely used (in the order of 1g per person per year). They pass the body largely unchanged and are also not degraded in wastewater treatment plants. With not too much effort, they may be eliminated from their effluents by ozonation. The macrolide antibiotics have all a dimethylamino group at one of the carbohydrate residues in common. This functional group is the target of the ozone reaction, and clarithromycin has been selected here for a more detailed study. Since only the free amine reacts with ozone, the rate of reaction is pH dependent (at pH 7: k = 4 x 10(4) M(-1) s(-1)). In analogy to the ozonolysis of trimethylamine, the main reaction is a transfer of an O-atom yielding the N-oxide (identified by HPLC/MS-MS). A minor product (10%, based on formaldehyde yields) is demethylated clarithromycin (identified by HPLC/MS-MS). The dimethylamino group is thought to be essential for the binding of the macrolide antibiotics to their target. As a consequence, chemical changes of this functional group, notably the formation of the N-oxide that is no longer a proton acceptor, inactivates these drugs as assayed by the suppression of the growth of Pseudomonas putida. This is most important for wastewater treatment, as mineralization of clarithromycin by ozone would require 100 times as much ozone.