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Ana-Marija Domijan Ana Marija Marjanović Čermak Ana Vulić Ivana Tartaro Bujak Ivan Pavičić Jelka Pleadin 《Journal of environmental science and health. Part. B》2019,54(3):155-162
Toxicity of gamma irradiated mycotoxins aflatoxin B1 (AFB1) and ochratoxin A (OTA) was investigated in vitro. AFB1 and OTA stock solutions (50?mM, in methanol) were gamma irradiated (5 and 10 kGy) and non-irradiated and irradiated mycotoxins solutions were tested for cytotoxicity on Pk15, HepG2 and SH-SY5Y cell lines (MTT assay, 1–500?μM concentration range; 24?h exposure). Degradation of mycotoxin molecules was examined by liquid chromatography tandem mass spectrometry (HPLC-MS/MS). AFB1 and OTA radiolytic products were less toxic than the parent mycotoxins to all of the tested cell lines. Gamma irradiation even at 5 kGy had effect on AFB1 and OTA molecules however, this effect was dependent on chemical structure of mycotoxin. Since gamma irradiation at low dose reduced initial level of both mycotoxins, and gamma irradiated mycotoxins had lower toxicity in comparison to non-irradiated mycotoxins, it can be concluded that gamma irradiation could be used as decontamination method. 相似文献
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Concentration of trace elements in blood and feed of homebred animals in Southern Serbia 总被引:1,自引:1,他引:0
Dragana Popovic Tatjana Bozic Jelka Stevanovic Marina Frontasyeva Dragana Todorovic Jelena Ajtic Vesna Spasic Jokic 《Environmental science and pollution research international》2010,17(5):1119-1128
Background, aim and scope
The paper presents concentrations of trace elements in blood of homebred animals (cows and sheep) from Southern Serbia (Bujanovac) and the contents of natural and anthropogenic radionuclides and some heavy metals in feed. The region of Southern Serbia was exposed to contamination by depleted uranium ammunition during NATO attacks in 1999 and therefore, is of great concern to environmental pollution and human and animal health. 相似文献
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