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C. Kesavachandran B. S. Pangtey V. Bihari M. Fareed M. K. Pathak A. K. Srivastava N. Mathur 《Environmental monitoring and assessment》2013,185(2):1265-1272
The World Health Organization has estimated that air pollution is responsible for 1.4 % of all deaths and 0.8 % of disability-adjusted life years. NOIDA, located at the National Capital Region, India, was declared as one of the critically air-polluted areas by the Central Pollution Control Board of the Government of India. Studies on the relationship of reduction in lung functions of residents living in areas with higher concentrations of particulate matter (PM) in ambient air were inconclusive since the subjects of most of the studies are hospital admission cases. Very few studies, including one from India, have shown the relationship of PM concentration and its effects of lung functions in the same location. Hence, a cross-sectional study was undertaken to study the effect of particulate matter concentration in ambient air on the lung functions of residents living in a critically air-polluted area in India. PM concentrations in ambient air (PM1, PM2.5) were monitored at residential locations and identified locations with higher (NOIDA) and lower concentrations (Gurgaon). Lung function tests (FEV1, PEFR) were conducted using a spirometer in 757 residents. Both air monitoring and lung function tests were conducted on the same day. Significant negative linear relationship exists between higher concentrations of PM1 with reduced FEV1 and increased concentrations of PM2.5 with reduced PEFR and FEV1. The study shows that reductions in lung functions (PEFR and FEV1) can be attributed to higher particulate matter concentrations in ambient air. Decline in airflow obstruction in subjects exposed to high PM concentrations can be attributed to the fibrogenic response and associated airway wall remodeling. The study suggests the intervention of policy makers and stake holders to take necessary steps to reduce the emissions of PM concentrations, especially PM1, PM2.5, which can lead to serious respiratory health concerns in residents. 相似文献
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Singh VK Pathak MK Bihari V Jyoti Patel DK Mathur N Kesavachandran CN Siddiqui MK 《Journal of environmental biology / Academy of Environmental Biology, India》2011,32(1):39-42
An important role of oxidative stress for the development of vascular and neurological complications has encouraged us to undertake a study to assess the oxidative stress induced nerve conduction deficits among cigarette smokers. Eighteen regular male cigarette smokers and twenty nine male non-smokers were diagnosed for clinical neuro-physiological tests viz., motor and sensory nerve conduction velocity (MNCV and SNCV) and redox status. Significant depletion of reduced glutathione (GSH) level (p < 0.05) and significant increase in malondialdehyde (MDA) level (p < 0.01) was found in smokers compared to non-smokers. Motor and sensory nerve conduction velocity showed no significant difference among smokers compared to non-smokers. The present study shows that smoking can induce oxidative stress among smokers but could not exacerbate to nerve conduction deficits. 相似文献
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Mohammad Fareed Chandrasekharan Nair Kesavachandran Manoj Kumar Pathak Vipin Bihari Mohammed Kuddus 《毒物与环境化学》2013,95(8):1601-1609
In this study, risk assessment for visual disturbances among farm workers spraying agricultural pesticides in farms have been assessed. A cross-sectional study for the assessment of visual disturbances was undertaken using questionnaire survey and clinical examination among agricultural workers exposed to pesticides. Two hundred and thirty nine pesticide sprayers participated in the study. The study was compared to 110 controls not occupationally exposed to pesticides with similar socio-economic status. The prevalence of ocular morbidity was found to be 40% among pesticide sprayers which was significantly higher (p?0.01) as compared to controls. The symptoms among morbid subjects were found to be blurred vision, lacrimation, pain in eyes, red swollen eyes, and irritation of eyes. Exposure wise assessment of ocular symptoms among pesticide sprayers illustrates that exposure time elevates the ocular problems among sprayers. The cholinesterase activity was found to be significantly depleted (p?0.01) among pesticide sprayers as compared to controls which show the exposure of organophosphate pesticides among them. The visual disturbances observed among pesticide sprayers clearly exhibit that eyes get exposed by pesticides during spraying operations in agriculture and eventually get affected leading to ocular illness. 相似文献
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Manoj Kumar Pathak Mohammad Fareed Anup Kumar Srivastava Balram Singh Pangtey Vipin Bihari Mohammed Kuddus C. Kesavachandran 《Environmental science and pollution research international》2013,20(10):7296-7300
Pesticide spraying operation is associated with the increased risk of adverse health effects among sprayers who do not follow safe farm work practices. A study was conducted among pesticide sprayers in North India to evaluate the clinical and subclinical variations in their vital health parameters before and after the pesticide spraying season. Blood cholinesterase levels, pulmonary function test, nerve conduction velocity and self-reported symptoms were studied among 18 eligible and consenting male sprayers. Mean acetylcholinesterase activity was reduced by 55 % in the post-exposure assessment (P?<?0.001) as compared to pre-exposure levels. Mean forced expiratory volume in 1 s was 20 % lower in the post-exposure assessment as compared to the pre-exposure level (P?<?0.05). No significant change was observed in the motor and sensory nerve conduction velocity in the median nerve of sprayers before and after the spraying activity. Also, no significant variation was observed with respect to self-reported symptoms except weakness in arms and legs (P?<?0.05). The significant decline in lung function and acetylcholinesterase level after pesticide exposure reflects the strongly negative effect of exposure to pesticides during spraying activity. More longitudinal studies among pesticide sprayers must be undertaken to further substantiate the cause–effect relationship between pesticide exposure and its subclinical effects. There is a strong necessity to minimise the exposure through the use of personal protective equipment in pesticide sprayers. 相似文献
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Kesavachandran Chandrasekharan Nair Prathish Krishna Pillai Sakhre Saurabh Ajay Sundaresan Vasanthi Rahul Chirackal Muraleedharan 《Environmental science and pollution research international》2022,29(21):30802-30807
Environmental Science and Pollution Research - The World Health Organization has proposed the ambient air quality guidelines 2021. The uniqueness of the guidelines of the World Health Organization... 相似文献
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