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Ashraf Sohaib Ashraf Shoaib Ashraf Moneeb Imran Muhammad Ahmad Choudhary Zawar Ahmad Hafsa Hadiqa Tul Awais Abeer Bin Kalsoom Larab Farooq Iqra Habib Zaighum Ashraf Sidra Iqbal Qurrat Ul Ain Ghufran Muhammad Sherazi Syed Sami Hussain Akram Muhammad Kiwan Akmal Rutaba Rafique Sundas Nawaz Khawar Safdar Zartasha Siddique Uzma Nasim Hassan Muhammad Arshad Shahroze Virk Abdul Rehman Ashraf Muhammad Saboor Qazi Abdul Humayun Ayesha Izhar Mateen 《Environmental science and pollution research international》2022,29(6):8382-8392
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Muhammad Furqan Akhtar Muhammad Ashraf Aqeel Javeed Aftab Ahmad Anjum Ali Sharif Mohammad Saleem Ghulam Mustafa Moneeb Ashraf Ammara Saleem Bushra Akhtar 《Environmental monitoring and assessment》2018,190(3):179
Complex industrial discharges pose certain risks to the ecosystem. This study was aimed at identifying acute and sub-chronic toxicological effects of the textile industry wastewater. The textile wastewater was evaluated for the metals and organic pollutants by atomic absorption spectrophotometer and GC-MS respectively. In vitro genotoxicity and mutagenicity were assessed by Comet assay in peripheral lymphocytes isolated from Ovis aries and Ames test in Salmonella typhimurium strains TA-100 and 102 respectively. Physiological and behavioral changes along with systemic toxicity were determined in Rattus norvegicus albinus following acute and sub-chronic exposure. High amount of heavy metals such as Cr, Pb, Hg, As, and Cd were detected in textile wastewater. Organic pollutants such as 25-deacetoxy cucurbitacin-b, E-14-Hexadecenal, 11-Tricosene, and phthalates were also found. In vitro genotoxicity assessment in lymphocytes showed statistically significant DNA damaging potential of textile wastewater. Textile wastewater also showed significantly higher (p? 0.05) mutagenic potential in Salmonella TA-100 and TA-102 strains than sodium azide and 2-amino anthracycline. Acute exposure of textile wastewater to Rattus norvegicus was associated with several physiological changes and behavioral symptoms. Sub-chronic exposure of textile wastewater in Rattus norvegicus instigated the degeneration and necrosis of epithelial cells in renal tubules, hydropic degeneration and necrosis of hepatocytes, peri-bronchiolar infiltration and emphysema of the alveoli, and the degradation of myocardial cells. This study concludes that the textile wastewater may cause genotoxicity and mutagenicity, result in physiological and behavioral changes upon acute exposure, and inflict various pathological lesions upon sub-chronic exposure. 相似文献
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