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Yohannes Yared Beyene Nakayama Shouta M. M. Yabe John Toyomaki Haruya Kataba Andrew Nakata Hokuto Muzandu Kaampwe Ikenaka Yoshinori Choongo Kennedy Ishizuka Mayumi 《Environmental science and pollution research international》2022,29(5):6622-6632
Environmental Science and Pollution Research - Interindividual genetic variations determine human’s susceptibility to heavy metal-induced toxicity. Thus, we analyzed blood concentrations of... 相似文献
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Shouta M. M. Nakayama Yoshinori Ikenaka Kyohei Hamada Kaampwe Muzandu Kennedy Choongo John Yabe Takashi Umemura Mayumi Ishizuka 《Environmental monitoring and assessment》2013,185(6):4907-4918
The lead–zinc (Pb–Zn) mine in Kabwe City and the copper–cobalt (Cu–Co) mine in the Copperbelt Province are major mining areas in Zambia. To examine the effects of metal pollution on wildlife, wild black rats (Rattus rattus and Rattus tanezumi) were captured in Kabwe and Chingola (in the Copperbelt Province), and in Lusaka (a noncontaminated site). Wild black rats in Kabwe accumulated significantly higher concentrations of Pb and Cd in various organs than rats from Lusaka. In Chingola, significantly higher concentrations of Cu, Co, Pb, and Cd were accumulated in wild black rats than in rats from Lusaka. These results were in accordance with metal accumulation patterns in soil. From toxicological aspects, concentrations of Pb and Cd in rats were generally low. However, metallothionein-1 (MT-1) and metallothionein-2 (MT-2) mRNA expression levels in wild black rats from Kabwe were significantly higher than those in rats from Lusaka. A generalized linear model (GLM) showed that concentrations of Zn and Cu had positive effects on the MT-1 and MT-2 mRNA expression. These results suggest that wild black rats in Zambian mining sites were exposed to metals that accumulated in their organs, causing biological responses such as MT mRNA induction. GLM indicated that heme oxygenase-1 (HO-1) mRNA expression could be a marker for Cr exposure. 相似文献
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Nakayama SM Ikenaka Y Hamada K Muzandu K Choongo K Teraoka H Mizuno N Ishizuka M 《Environmental pollution (Barking, Essex : 1987)》2011,159(1):175-181
Metal (Cr, Co, Cu, Zn, Cd, Pb, Ni) and metalloid (As) accumulation was studied in roadside soil and wild rat (Rattus sp.) samples from near a Pb-Zn mine (Kabwe, Zambia) and the capital city of Zambia (Lusaka). The concentrations of the seven metals and As in the soil samples and Pb in the rat tissue samples were quantified using atomic absorption spectroscopy. The concentrations of Pb, Zn, Cu, Cd, and As in Kabwe soil were much higher than benchmark values. Geographic Information System analysis indicated the source of metal pollution was mining and smelting activity. Interestingly, the area south of the mine was more highly contaminated even though the prevailing wind flow was westward. Wild rats from Kabwe had much higher tissue concentrations of Pb than those from Lusaka. Their body weight and renal Pb levels were negatively correlated, which suggests that mining activity might affect terrestrial animals in Kabwe. 相似文献
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