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An integrated assessment of estrogenic contamination and biological effects in the aquatic environment of The Netherlands 总被引:18,自引:0,他引:18
Vethaak AD Lahr J Schrap SM Belfroid AC Rijs GB Gerritsen A de Boer J Bulder AS Grinwis GC Kuiper RV Legler J Murk TA Peijnenburg W Verhaar HJ de Voogt P 《Chemosphere》2005,59(4):511-524
An extensive study was carried out in the Netherlands on the occurrence of a number of estrogenic compounds in surface water, sediment, biota, wastewater, rainwater and on the associated effects in fish. Compounds investigated included natural and synthetic hormones, phthalates, alkylphenol(ethoxylate)s and bisphenol-A. The results showed that almost all selected (xeno-)estrogens were present at low concentrations in the aquatic environment. Locally, they were found at higher levels. Hormones and nonylphenol(ethoxylate)s were present in concentrations that are reportedly high enough to cause estrogenic effects in fish. Field surveys did not disclose significant estrogenic effects in male flounder (Platichthys flesus) in the open sea and in Dutch estuaries. Minor to moderate estrogenic effects were observed in bream (Abramis brama) in major inland surface waters such as lowland rivers and a harbor area. The prevalence of feminizing effects in male fish is largest in small regional surface waters that are strongly influenced by sources of potential hormone-disrupting compounds. High concentrations of plasma vitellogenin and an increased prevalence of ovotestes occurred in wild male bream in a small river receiving a considerable load of effluent from a large sewage treatment plant. After employing in vitro and in vivo bioassays, both in situ and in the laboratory, we conclude that in this case hormones (especially 17 alpha-ethynylestradiol) and possibly also nonylphenol(ethoxylate)s are primarily responsible for these effects. 相似文献
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YOAN PAILLET LAURENT BERGÈS JOAKIM HJÄLTÉN PÉTER ÓDOR CATHERINE AVON MARKUS BERNHARDT‐RÖMERMANN RIENK‐JAN BIJLSMA LUC DE BRUYN MARC FUHR ULF GRANDIN ROBERT KANKA LARS LUNDIN SANDRA LUQUE TIBOR MAGURA SILVIA MATESANZ ILONA MÉSZÁROS M.‐TERESA SEBASTIÀ WOLFGANG SCHMIDT TIBOR STANDOVÁR BÉLA TÓTHMÉRÉSZ ANNELI UOTILA FERNANDO VALLADARES KAI VELLAK RISTO VIRTANEN 《Conservation biology》2010,24(4):1157-1160
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In order to validate a classification system for the prediction of the toxic effect concentrations of organic environmental pollutants to fish, all available fish acute toxicity data were retrieved from the ECETOC database, a database of quality-evaluated aquatic toxicity measurements created and maintained by the European Centre for the Ecotoxicology and Toxicology of Chemicals. The individual chemicals for which these data were available were classified according to the rulebase under consideration and predictions of effect concentrations or ranges of possible effect concentrations were generated. These predictions were compared to the actual toxicity data retrieved from the database. The results of this comparison show that generally, the classification system provides adequate predictions of either the aquatic toxicity (class 1) or the possible range of toxicity (other classes) of organic compounds. A slight underestimation of effect concentrations occurs for some highly water soluble, reactive chemicals with low log K(ow) values. On the other end of the scale, some compounds that are classified as belonging to a relatively toxic class appear to belong to the so-called baseline toxicity compounds. For some of these, additional classification rules are proposed. Furthermore, some groups of compounds cannot be classified, although they should be amenable to predictions. For these compounds additional research as to class membership and associated prediction rules is proposed. 相似文献
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