全氟羟基物质在冠海豹(Hooded seals)体内的母源性传递

在野生动物物种中,乳汁在传递全氟烃基物质(PFASs)于后代中所起的作用,人类还了解甚少。本文以雌性冠海豹及其生产的一对幼崽为研究对象,在哺乳期间,对母体血浆和乳汁中的8种PFASs进行了定量检测,以及对乳汁在PFASs传递过程中所起的作用进行了分析。选择冠海豹是因为它的泌乳周期短(3~ 4 d),在此期间幼崽仅以乳汁为食。胎盘或乳汁传递成为幼崽体内PFASs的唯一来源。通过对8种PFASs的分析(Σ8PFAS),发现7种存在于所有样品中;因此,乳汁是幼崽体内PFASs的来源。在所有样本中,全氟辛烷磺酰基化合物是优势PFAS。Σ8PFAS的平均浓度为母体血浆中6.0 ng/g蛋白(36 ng/g湿重),乳汁中0.77 ng/g蛋白(3.2 ng/g湿重)以及幼崽血浆中12 ng/g蛋白(66 ng g湿重)。血浆中检测到的PFASs浓度在已有报道的其他海豹物种体内检测到的浓度范围之内,低于已知的实验啮齿动物的毒性阈值。PFASs从母体到幼崽的传递效率的个体差异,依赖于PFASs碳键长度、相对传递量最低的为中间能级键的PFASs (C9-C10)。结果显示母体通过乳汁和胎盘传递PFASs,其中胎盘传递是主导途径。
精选自Randi Gr?nnestad, Gro D. Villanger, Anuschka Polder, Kit M. Kovacs, Christian Lydersen, Bj?rn M. Jenssen, Katrine Borg?. Maternal transfer of perfluoroalkyl subastances in hooded seals. Environmental Toxicology and Chemistry: Volume 36, Issue 3, pages 763–770, July 2017. DOI: 10.1002/etc.3623
详情请见http://onlinelibrary.wiley.com/wol1/doi/10.1002/etc.3623/full
     

Exposure to mixtures of organohalogen contaminants and associative interactions with thyroid hormones in East Greenland polar bears (Ursus maritimus)

We investigated the multivariate relationships between adipose tissue residue levels of 48 individual organohalogen contaminants (OHCs) and circulating thyroid hormone (TH) levels in polar bears (Ursus maritimus) from East Greenland (1999-2001, n=62), using projection to latent structure (PLS) regression for four groupings of polar bears; subadults (SubA), adult females with cubs (AdF_N), adult females without cubs (AdF_S) and adult males (AdM). In the resulting significant PLS models for SubA, AdF_N and AdF_S, some OHCs were especially important in explaining variations in circulating TH levels: polybrominated diphenylether (PBDE)-99, PBDE-100, PBDE-153, polychlorinated biphenyl (PCB)-52, PCB-118, cis-nonachlor, trans-nonachlor, trichlorobenzene (TCB) and pentachlorobenzene (QCB), and both negative and positive relationships with THs were found. In addition, the models revealed that DDTs had a positive influence on total 3,5,3'-triiodothyronine (TT3) in AdF_S, and that a group of 17 higher chlorinated ortho-PCBs had a positive influence on total 3,5,3',5'-tetraiodothyronine (thyroxine, TT4) in AdF_N. TH levels in AdM seemed less influenced by OHCs because of non-significant PLS models. TH levels were also influenced by biological factors such as age, sex, body size, lipid content of adipose tissue and sampling date. When controlling for biological variables, the major relationships from the PLS models for SubA, AdF_N and AdF_S were found significant in partial correlations. The most important OHCs that influenced TH levels in the significant PLS models may potentially act through similar mechanisms on the hypothalamic-pituitary-thyroid (HPT) axis, suggesting that both combined effects by dose and response addition and perhaps synergistic potentiation may be a possibility in these polar bears. Statistical associations are not evidence per se of biological cause-effect relationships. Still, the results of the present study indicate that OHCs may affect circulating TH levels in East Greenland polar bears, adding to the "weight of evidence" suggesting that OHCs might interfere with thyroid homeostasis in polar bears.