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Toropov AA Toropova AP Benfenati E Gini G Puzyn T Leszczynska D Leszczynski J 《Chemosphere》2012,89(9):1098-1102
Convenient to apply and available on the Internet software CORAL (http://www.insilico.eu/CORAL) has been used to build up quantitative structure-activity relationships (QSAR) for prediction of cytotoxicity of metal oxide nanoparticles to bacteria Escherichia coli (minus logarithm of concentration for 50% effect pEC50). In this study six random splits of the data into the training and test set were examined. It has been shown that the CORAL provides a reliable tool that could be used to build up a QSAR of the pEC50. 相似文献
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Svetoslav Slavov Giuseppina Gini Emilio Benfenati 《Journal of environmental science and health. Part. B》2013,48(8):633-637
The pesticides originally designed to kill target organisms are dangerous for many other wild species. Since they are applied directly to the environment, they can easily reach the water basins and the topsoil. A dataset of 125 aromatic pesticides with well-expressed aquatic toxicity towards trout was subjected to quantitative structure activity relationships (QSAR) analysis aimed to establish the relationship between their molecular structure and biological activity. A literature data for LC50 concentration killing 50% of fish was used. In addition to the standard 2D-QSAR analysis, a comparative molecular field analysis (CoMFA) analysis considering the electrostatic and steric properties of the molecules was also performed. The CoMFA analysis helped the recognition of the steric interactions as playing an important role for aquatic toxicity. In addition, the transport properties and the stability of the compounds studied were also identified as important for their biological activity. 相似文献
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Luciana Migliore Gianfranco Brambilla Paolo Casoria Cinzia Civitareale Salvatore Cozzolino Luciano Gaudio 《Agriculture, ecosystems & environment》1996,60(2-3)
Animal wastes from intensive farming are generally collected for field fertilisation. They may contain drugs that can become soil pollutants. To evaluate the possible effects of such contamination in terrestrial systems, sulphadimethoxine has been subjected to laboratory tests (in vitro, synthetic medium, and soil) using seeds of barley (Hordeum distichum L.). The drug suppressed normal post-germinative development and growth of roots and leaves in both test conditions; this effect was dependent on the bioaccumulation rate, which was higher on synthetic medium than in soil. Bioaccumulation was higher in roots than foliage and this was markedly evident in soil and, in particular, in soils with a low humus content. The environmental risk of sludge application on soils and the possible contamination of food chains are discussed. 相似文献
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Phytotoxicity to and uptake of flumequine used in intensive aquaculture on the aquatic weed, Lythrum salicaria L 总被引:6,自引:0,他引:6
Phytotoxicity of Flumequine on the aquatic weed Lythrum salicaria L. was determined by two laboratory models: a single concentration test, by which the effects of 100 mg l-1 were evaluated after 10, 20, 30 days and a multiple concentration test, by which the effects of 5000-1000-500-100-50 micrograms l-1 were evaluated after 35-day exposure. 100 mg l-1 are highly toxic and significantly decrease the growth of plants; this effect increases with time. Concentrations between 5000 and 50 micrograms l-1 induced hormesis in plants, by significantly increasing mean number and dimension of leaves and secondary roots. The effect is the highest at 50 micrograms l-1 and decreases with increase in concentration. Both toxic effect and hormesis can be related to plant drug uptake, quite high, in the order of micrograms g-1. The ecological implication of Flumequine contamination in aquatic environments and the possible use of Lythrum salicaria for bioremediation and/or monitoring technique are discussed. 相似文献
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Mancini Pamela Bonanno Ferraro Giusy Suffredini Elisabetta Veneri Carolina Iaconelli Marcello Vicenza Teresa La Rosa Giuseppina 《Food and environmental virology》2020,12(1):68-74
Food and Environmental Virology - Salivirus (SalV) is a newly discovered virus associated to acute gastroenteritis in humans. In Italy, its prevalence and genetic diversity is unknown. To reduce... 相似文献
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Giovanni Monni MD Rosa M. Ibba Rosalba Laj Cau Giuseppina Mura Silvia Giovanni Olla Antonio Cao 《黑龙江环境通报》1992,12(10):815-820
In this paper we report the fetal loss rate in relation to both maternal and gestational age in 1764 pregnant women who underwent transabdominal chorionic villus sampling (TA-CVS) between January 1986 and August 1990. The fetal loss rate, considered as a proportion of continuing pregnancies, decreased with advancing gestational age at sampling from 4.3 per cent before 9 weeks to 0.4 per cent at or after 13 weeks, the difference being statistically significant (p <0.025). The fetal loss rate increased from 1.6 per cent in women under 30 to 2.4 per cent in women of 40 years or over, but the difference was not statistically significant. Considering that the total fetal loss rate before 28 weeks' gestation was on average 1.91 percent (1.3 per cent under 35 years and 2.8 per cent in women of 35 or over), we believe that TA-CVS is a safe and effective technique for prenatal diagnosis of genetic diseases. 相似文献
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Environmental features of two commercial surfactants widely used in soil remediation 总被引:1,自引:0,他引:1
One of the main limitations for a wider application of surfactants in soil remediation is the lack of knowledge about environmental fate and toxicity of surfactant itself especially for in situ application. Sorption behaviour, biodegradability, toxicity of parent compound and its metabolites are important processes that affect environmental fate of surfactants in site remediation applications. Tween 80 (poly(oxyethylene)(20)-sorbitane monooleate) and Aerosol MA+80 (dihexyl sodium sulfosuccinate) are surfactants that have been tested in laboratory and field scale remediation of soil and groundwater. In this work, the sorption and biodegradability of these surfactants were assessed to provide conditions and limitations for their use. The soil used in this experimentation was analysed for organic carbon content, soil bacteria, and size fraction and resulted to be a good model because is characterised by mean values for almost all considered parameters. Tween 80 showed high degree of biodegradability but a high affinity for soil matrix. Results suggest that Tween 80 could find its best application in ex situ solid phase remediation like ex situ bioremediation; its high affinity to soil could limit in situ applications. Biodegradation tests for Aerosol MA+80 show low degree of biodegradability and mineralisation. Biodegradation experiments, coupled with analysis of toxicity, could support the hypothesis that degradation of Aerosol MA+80 is not complete and leads to an accumulation of intermediates with at least the same toxicity of the parental compound. Therefore, aquifer remediation application with Aerosol MA+80 has to be conducted with necessary precautions to avoid product loss and excess surfactant should be flushed from the soil. 相似文献