Gemfibrozil modulates cytochrome P450 and peroxisome proliferation-inducible enzymes in the liver of the yellow European eel (Anguilla anguilla)

The human lipid regulator gemfibrozil (GEM) has been shown to induce peroxisome proliferation in rodents leading to hepatocarcinogenesis. Since GEM is found at biological active concentrations in the aquatic environment, the present study investigates the effects of this drug on the yellow European eel (Anguilla anguilla). Eels were injected with different concentrations of GEM (0.1 to 200 μg/g) and sampled 24- and 96-h post-injection. GEM was shown to inhibit CYP1A, CYP3A and CYP2K-like catalytic activities 24-h post-injection, but at 96-h post-injection, only CYP1A was significantly altered in fish injected with the highest GEM dose. On the contrary, GEM had little effect on the phase II enzymes examined (UDP-glucuronyltransferase and glutathione-S-transferase). Peroxisome proliferation inducible enzymes (liver peroxisomal acyl-CoA oxidase and catalase) were very weakly induced. No evidence of a significant effect on the endocrine system of eels was observed in terms of plasmatic steroid levels or testosterone esterification in the liver.     

Organic Agriculture’s Approach towards Sustainability; Its Relationship with the Agro-Industrial Complex, A Case Study in Central Macedonia, Greece

Up to now, several scientific works have noted that the organic sector resembles more and more conventional farming’s structures, what is widely known as the “conventionalization” thesis. This phenomenon constitutes an area of conflict between organic farming’s original vision and its current reality and raises ethical and social questions concerning the structure of agricultural systems of production and their interactions with the socio-economic and natural environment. The main issue of this dialogue is the concept of sustainable agriculture, which for scientists and policymakers is a means to express their vision of a better agriculture. In this article we focus on agricultural sustainability in the context of capitalist production as conducted by the two subsystems of agro-industrial system. As we have proposed in this article, the relationship between organic agriculture, defined by two essential components (prevention and direct marketing), and the agro-industrial complex, defined by two subsystems, indicates the degree of agricultural sustainability. The investigation of this relationship can be extremely useful as it may lead those involved in the discussion of sustainability to identify the key aspects of sustainable agriculture. In order to investigate the interaction of organic farming with the agro-industrial complex, a survey was conducted in Central Macedonia, Northern Greece, involving local organic farms. The results of our study indicate that a large proportion of organic producers did not differ substantially from their counterparts in conventional agriculture in so far as their relationship with the agro-industrial complex is concerned. Finally, this research highlights two scenarios for the evolution of organic farming. The first is the full absorption of organic farming to the existing economic system and the second one is the development of organic farming in a radically opposite direction to conventional farming.     

A high-resolution climatological study on the comparison between surface explosive and ordinary cyclones in the Mediterranean

The dynamic and kinematic characteristics of surface explosive cyclones in the Mediterranean are examined and compared to those of ordinary cyclones. The cyclone detection is performed with the tracking algorithm developed in the University of Melbourne, using the 1° × 1° ERA-40 mean sea level pressure dataset for a 40 year period. It is verified that the explosive cyclogenesis in the Mediterranean is mainly a maritime phenomenon, occurring along the northern Mediterranean coast during the cold season. On the contrary, the ordinary cyclogenesis exhibits significant maxima in both continental and maritime environments throughout the year. The explosive cyclones are characterized by longer lifetime and greater propagation speed. They are larger and deeper in the eastern Mediterranean, whereas the ordinary cyclones are deeper in the western and larger in the eastern Mediterranean. The trend analysis revealed that both explosive and ordinary cyclones become less frequent in the Mediterranean basin, while there is a tendency for deeper ordinary cyclones over North Africa and shallower over the Aegean Sea and Cyprus.     

Maternal serum leptin concentration during the second trimester of pregnancy: association with fetal chromosomal abnormalities

Recent studies suggest that leptin, the product of the obese gene, is produced by the placenta during pregnancy. The present study addressed the question whether second trimester maternal serum leptin could be altered by fetal Down syndrome or Edwards syndrome. Maternal serum leptin concentrations were measured in 18 pregnancies complicated with Down syndrome, six pregnancies complicated with Edwards syndrome and 183 uncomplicated pregnancies during the second trimester of pregnancy. The present results demonstrate that leptin concentrations in uncomplicated pregnancies slightly decrease from the 16th week of pregnancy, reaching a minimum of 18.8 ng/ml around the 20th week, and then rapidly increase to 28.2 ng/ml by the 24th week. Leptin correlation with maternal body weight decreases from r=0.695 at 16–17 week of gestation to r=0.544 at >22 weeks of gestation. There was no significant difference between the mean MoMs of Down syndrome- (0.926) or Edwards syndrome- (0.960) affected pregnancies and normal pregnancies (1.002). A weak correlation (r=0.18, p<0.02) was observed between corrected leptin MoMs and human chorionic gonadotrophin (hCG) MoMs in normal pregnancies. It is assumed that around the 20th week of pregnancy placental leptin production is activated or at least is accelerated and it is added to the amount of leptin produced by maternal adipose tissue. Fetal Down syndrome or Edwards syndrome does not seem to alter maternal leptin concentration and therefore leptin cannot be used as a marker for these chromosomal abnormalities in the early second trimester of pregnancy. Copyright © 2002 John Wiley & Sons, Ltd.     

Assessing the Impact of Pluriactivity on Sustainable Agriculture. A Case Study in Rural Areas of Beotia in Greece

Pluriactivity of farms, or part-time farming, is a common feature of agriculture in all countries regardless of their socioeconomic system and level of development. Currently, pluriactivity is related to the values of sustainable agriculture. The objective of this study is to delineate those specific characteristics of pluriactive farms that contribute to sustainable agriculture. In rural areas of Boetia in Greece, a socioeconomic survey was carried out on 114 farms to determine the types of farming applied. The results demonstrate that pluriactivity is a stable component of the agricultural structure in the rural areas of Boetia. It is widespread in plains, but its presence is more important in mountainous and semimountainous areas. The choice of young farmers is to opt for pluriactivity. Farm size does not differ between pluriactive and full-time farms. Pluriactive and full- time farms use the same level of input and get the same output for the same type of crop. However, pluriactive farmers under the same land-productive conditions are oriented toward a more extensive farming system, managing their land with crops that need less inputs. Considering these findings, it can be claimed that pluriactivity can contribute to diminishing the demand on natural resources in favored (level and irrigated) areas, to continue agricultural production in unfavorable (mountainous and semimountainous) areas, and to help the sustenance of the rural population.     

Spatial Patterns of Macrobenthic Communities in Shallow-Water Tidal Embayments and Their Association with Environmental Factors

This study examines the distribution, composition, and structure of benthic communities in nine shallow-water semienclosed embayments on Cape Cod, southeastern Massachusetts. The spatial patterns were used to associate benthic characteristics with local environmental factors. Field data from multiple years were collected to measure macrofaunal abundance, community composition, and environmental characteristics. Multivariate statistics were used to analyze the spatial variations of species composition and the abundance of benthic macrofauna. Canonical ordination, specifically redundancy analysis, was used to determine the relative importance of the environmental factors (nutrients and habitat factors) being studied. The analyses demonstrate that the benthic communities in the shallow tidal embayments are clearly clustered in association with the local environments. Species composition and community structure of the benthic macrofauna are significantly correlated with water column parameters, especially with phytoplankton biomass, total nitrogen, and dissolved oxygen.     

“Housing for all” at the era of financialization; can (post-disaster) cities become truly socially resilient and egalitarian?

This paper examines the realism of the resilience ambition and process of the U.S. housing system, shedding light on its heterogeneity as well as the financialization currently acting as the driving force in real estate production. The resilience ambition leading to enhanced justice and egalitarianism is understood as the provision and maintenance of post-disaster housing for all within an institutionally diverse landscape of housing policy makers and implementers. Particular emphasis is given to the post-Katrina institutional transformations resulting from multifarious interactions between multilevel institutional structures and a diverse landscape of low-income housing policy implementers – referred as social resilience cells (SRCs) in this paper. The nature and level of these transformations determine the degree to which resilience in its heterogeneous form has been incubated in New Orleans. The paper concludes with a discussion on the macro conditions and bottom-linked governance structures under which all SRCs could be better bolstered in a post-financialization, radicalised neowelfare U.S., and which in turn create possibilities for materialising the resilience ambition.     

Triphenyltin alters lipid homeostasis in females of the ramshorn snail Marisa cornuarietis

Molluscs are sensitive species to the toxic effects of organotin compounds, particularly to masculinisation. Both tributyltin (TBT) and triphenyltin (TPT) have been recently shown to bind to mollusc retinoid X receptor (RXR). If RXR is involved in lipid homeostasis, exposure to TPT would have an immediate effect on endogenous lipids. To test this hypothesis, the ramshorn snail Marisa cornuarietis was exposed to environmentally relevant concentrations of TPT (30, 125, 500 ng/L as Sn) in a semi-static water regime for 7 days. Percentage of lipids and total fatty acid content decreased significantly in TPT-exposed females while the activity of peroxisomal acyl-CoA oxidase, involved in fatty acid catabolism, increased. In addition, fatty acid profiles (carbon chain length and unsaturation degree) were significantly altered in exposed females but not in males. This work highlights the ability of TPT to disrupt lipid metabolism in M. cornuarietis at environmentally realistic concentrations and the higher susceptibility of females in comparison to males.