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Sorption of sulfonamide pharmaceutical antibiotics on whole soils and particle-size fractions 总被引:6,自引:0,他引:6
Thiele-Bruhn S Seibicke T Schulten HR Leinweber P 《Journal of environmental quality》2004,33(4):1331-1342
Residues of pharmaceutical antibiotics are found in the environment, whose fate and effects are governed by sorption. Thus, the extent and mechanisms of the soil sorption of p-aminobenzoic acid and five sulfonamide antibiotics (sulfanilamide, sulfadimidine, sulfadiazine, sulfadimethoxine, and sulfapyridine) were investigated using topsoils of fertilized and unfertilized Chernozem and their organic-mineral particle-size fractions. Freundlich adsorption coefficients (K(f)) ranged from 0.5 to 6.5. Adsorption increased with aromaticity and electronegativity of functional groups attached to the sulfonyl-phenylamine core. Adsorption to soil and particle-size fractions increased in the sequence: coarse silt < whole soil < medium silt < sand < clay < fine silt and was influenced by pH. Sorption nonlinearity (1/n = 0.76) indicated specific interactions with functional groups of soil organic matter (SOM). Phenolic and carboxylic groups, N-heterocyclic compounds, and lignin decomposition products were tentatively assigned as preferred binding sites using statistical analysis of pyrolysis-mass spectra and adsorption coefficients. Adsorption of sulfonamides to mineral soil colloids was weaker and resulted in a stronger desorption from clay-size fractions. Moreover, steric accessibility of organic-mineral complexes in clay-size fractions was significantly reduced. With a quantitative structure-property relationship (QSPR) model, combining the organic carbon concentration, the sulfonamides' chromatographic capacity factor (k'), and nondissociated species concentration (CF(a)), distribution coefficients (K(d)) were estimated with a cross-validated regression coefficient Q(2) = 0.71. Modeling and molecular mechanics calculations of antibiotic-SOM complexes showed preferred site-specific sorption via hydrogen bonds and van der Waals interactions. Distinct chemical structural properties, such as aromaticity and van der Waals volumes, correlated with the sorption data. 相似文献
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Kotzerke A Sharma S Schauss K Heuer H Thiele-Bruhn S Smalla K Wilke BM Schloter M 《Environmental pollution (Barking, Essex : 1987)》2008,153(2):315-322
Most veterinary drugs enter the environment via manure application. However, it is unclear how these substances interact with soil biota. Therefore, it was the aim of the present study to investigate the effects of manure containing different concentrations of the antibiotic sulfadiazine (SDZ) on the soil microbial communities. It was shown that manure alone has a stimulating effect on microbial activity. Only potential nitrification was negatively influenced by manure application. The addition of SDZ to the manure reduced microbial activity. Depending on the SDZ concentration, levels of activity were in the range of the control soil without manure application. Also, selected processes in nitrogen turnover were negatively influenced by the addition of SDZ to the manure, with nitrification being the only exception. The effects were visible for up to 4 days after application of the manure with or without SDZ and were correlated with the bioavailability of the antibiotic. 相似文献
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Zhang Wei Tang Xiangyu Thiele-Bruhn Sören 《Environmental geochemistry and health》2021,43(10):4299-4313
Environmental Geochemistry and Health - Pharmaceutically active compounds (PhACs) released into the environment have an adverse impact on the soil and water ecosystem as well as human health.... 相似文献
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Distribution of sulfamethazine, chlortetracycline and tylosin in manure and soil of Canadian feedlots after subtherapeutic use in cattle 总被引:7,自引:0,他引:7
Aust MO Godlinski F Travis GR Hao X McAllister TA Leinweber P Thiele-Bruhn S 《Environmental pollution (Barking, Essex : 1987)》2008,156(3):1243-1251
Feedlots are potential point sources for the flow of antibiotics into the environment due to common use of antibiotics such as sulfamethazine, chlortetracycline and tylosin. Hence soils and manures originating from a grassland control, an experimental and a commercial feedlot were analyzed and mass balances were calculated for these antibiotics. Up to 9990 μg kg−1 sulfamethazine and 401 μg kg−1 chlortetracycline on a dry matter basis were determined in feedlot manure. Soil concentrations were two orders of magnitude smaller. This corresponds to 7-40% of the calculated residual amount. In the commercial feedlot chlortetracycline was found down to soil depths of −40 cm; sulfamethazine was still detectable 1 year after medication. Sulfamethazine and chlortetracycline were additionally determined in manure of a control treatment in the experimental feedlot where cattle never received antibiotics. This was attributed to runoff from upslope pens. Consequently, antibiotics partially persist within feedlots and may be dislocated into the surrounding environment by vertical transport and runoff. 相似文献
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Effects of sulfonamide and tetracycline antibiotics on soil microbial activity and microbial biomass 总被引:32,自引:0,他引:32
Increasingly often soil residual concentrations of pharmaceutical antibiotics are detected, while their ecotoxic relevance is scarcely known. Thus, dose related effects of two antibiotics, sulfapyridine and oxytetracycline, on microorganisms of two different topsoils were investigated. The fumigation-extracted microbial C (E(C)) and ergosterol were determined to indicate soil microbial and fungal biomass, respectively. Microbial activity was tested as basal respiration (BR), dehydrogenase activity (DHA), substrate-induced respiration (SIR), and Fe(III) reduction. The BR and DHA were uninfluenced even at antibiotic concentrations of 1000 microg g(-1). This revealed that an activation of microbial growth through nutrient substrate addition is required to test possible effects of the bacteriostatic antibiotics. In addition, the effects of both antibiotics were time dependent, showing that short-term tests were not suitable. Clear dose-response relations were determined with SIR when the short-term incubation of 4h was extended into the growth phase of the microorganisms (24 and 48 h). The Fe(III) reduction test, with a 7-d incubation, was also found to be suitable for toxicity testing of antibiotics in soils. Effective doses inhibiting the microbial activity by 10% (ED(10)) ranged from total antibiotic concentrations of 0.003-7.35 microg g(-1), depending on the antibiotic compound and its soil adsorption. Effective solution concentrations (EC(10)), calculated from distribution coefficients, ranged from 0.2 to 160 ng g(-1). The antibiotics significantly (p<0.05) reduced numbers of soil bacteria, resulting in dose related shifts in the fungal:bacterial ratio, which increased during 14 d, as determined from analysis of ergosterol and E(C). It was concluded that pharmaceutical antibiotics can exert a temporary selective pressure on soil microorganisms even at environmentally relevant concentrations. 相似文献
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