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Keeping the blood flowing—plasminogen activator genes and feeding behavior in vampire bats 总被引:1,自引:0,他引:1
Tellgren-Roth A Dittmar K Massey SE Kemi C Tellgren-Roth C Savolainen P Lyons LA Liberles DA 《Die Naturwissenschaften》2009,96(1):39-47
The blood feeding vampire bats emerged from New World leaf-nosed bats that fed on fruit and insects. Plasminogen activator,
a serine protease that regulates blood coagulation, is known to be expressed in the saliva of Desmodus rotundus (common vampire bat) and is thought to be a key enzyme for the emergence of blood feeding in vampire bats. To better understand
the evolution of this biological function, we studied the plasminogen activator (PA) genes from all vampire bat species in
light of their feeding transition to bird and subsequently mammalian blood. We include the rare species Diphylla ecaudata and Diaemus youngi, where plasminogen activator had not previously been studied and demonstrate that PA gene duplication observed in Desmodus is not essential to the vampire phenotype, but relates to the emergence of predominant mammalian blood feeding in this species.
Plasminogen activator has evolved through gene duplication, domain loss, and sequence evolution leading to change in fibrin-specificity
and susceptibility to plasminogen activator inhibitor-1. Before undertaking this study, only the four plasminogen activator
isoforms from Desmodus were known. The evolution of vampire bat plasminogen activators can now be linked phylogenetically to the transition in feeding
behavior among vampire bat species from bird to mammalian blood.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献
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Tao Ming Nie Kemi Zhao Rui Shi Ying Cao Wenzhuo 《Environmental science and pollution research international》2022,29(58):87613-87627
Environmental Science and Pollution Research - China is a major producer of copper concentrate as its smelting capacity continues to expand dramatically. The present study analyzes the life cycle... 相似文献
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