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Intissar Grissa Sabrine Guezguez Lobna Ezzi Sana Chakroun Amira Sallem Emna Kerkeni Jaber Elghoul Lassaad El Mir Meriem Mehdi Hassen ben Cheikh Zohra Haouas 《Environmental science and pollution research international》2016,23(20):20205-20213
Titanium dioxide nanoparticles (TiO2 NPs) are widely used for their whiteness and opacity in several applications such as food colorants, drug additives, biomedical ceramic, and implanted biomaterials. Research on the neurobiological response to orally administered TiO2 NPs is still limited. In our study, we investigate the effects of anatase TiO2 NPs on the brain of Wistar rats after oral intake. After daily intragastric administration of anatase TiO2 NPs (5–10 nm) at 0, 50, 100, and 200 mg/kg body weight (BW) for 60 days, the coefficient of the brain, acethylcholinesterase (AChE) activities, the level of interleukin 6 (IL-6), and the expression of glial fibrillary acidic protein (GFAP) were assessed to quantify the brain damage. The results showed that high-dose anatase TiO2 NPs could induce a downregulated level of AChE activities and showed an increase in plasmatic IL-6 level as compared to the control group accompanied by a dose-dependent decrease inter-doses, associated to an increase in the cerebral IL-6 level as a response to a local inflammation in brain. Furthermore, we observed elevated levels of immunoreactivity to GFAP in rat cerebral cortex. We concluded that oral intake of anatase TiO2 NPs can induce neuroinflammation and could be neurotoxic and hazardous to health. 相似文献
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Rouibah Ikram Hassen Wafa Sallem Ons Fekih Khellaf Nabila Hassen Abdennaceur Mansour Hedi Ben 《Environmental science and pollution research international》2021,28(12):14530-14545
Environmental Science and Pollution Research - Medicines and drugs consumption by all populations of the world can be expected to result in the contamination of the environment since 30–90%... 相似文献
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