Associations between co-exposure to multiple metals and renal function: a cross-sectional study in Guangxi,China

The association between co-exposure to multiple metals and renal function is poorly understood. We aimed to evaluate the individual and joint effects of metal exposure on renal function in this study. We performed a cross-sectional study including 5828 participants in Guangxi, China, in 2019. Urine concentrations of 17 metals were detected by inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression model and restricted cubic spline (RCS) were applied to investigate the association of individual metal exposure with renal dysfunction. Weighted quantile sum (WQS) regression and Bayesian kernel machine regression (BKMR) were used to assess the co-exposure effects of the metals. Participants with the highest quartile of urinary Cu were at 1.84-fold (95% confidence interval (CI): 1.20–2.87) increased risk of renal dysfunction compared with the lowest quartile. The highest quartiles of urinary Sr, Cs, V, Ba, and Se were associated with 0.27-fold (95% CI: 0.17–0.43), 0.33 (95% CI: 0.19–0.53), 0.41 (95% CI: 0.25–0.65), 0.58 (95% CI: 0.36–0.90), and 0.33 (95% CI: 0.19–0.56) decreased risk of renal dysfunction compared with their lowest quartile, respectively. Furthermore, urinary Ba and Cu were non-linearly correlated with renal dysfunction. The WQS analysis showed that mixed metal exposure was inversely associated with renal dysfunction (OR = 0.47, 95% CI: 0.35–0.62), and Sr accounted for the largest weight (52.2%), followed by Cs (32.3%) in the association. Moreover, we observed a potential interaction between Cu, Cs, and Ba for renal dysfunction in BKMR model. Exposure to Se, Sr, Cs, V, and Ba is associated with decreased risk of renal dysfunction, whereas an increased risk is associated with Cu exposure. Co-exposure to these metals is negatively associated with renal dysfunction, and Sr and Cs are the main contributors to the associations.

     

高校宿舍楼火灾及人员疏散数值研究

为研究高校宿舍火灾烟气蔓延过程与人员疏散效果的相关联系,利用数值模拟研究了不同火灾场景下烟气流动、能见度、温度随时间变化的规律,及其对人员安全疏散的影响。研究表明:(1)火灾发生后,由于烟囱效应,烟气迅速在楼梯间蓄积,形成蓄烟池效应,堵塞疏散通道,然后逐渐发展至上部的楼层空间,对人员安全疏散极为不利;(2)高校宿舍楼人员较为集中,火灾发生时疏散人员在楼梯间易出现拥堵,人员火灾安全疏散的形势较为严峻;(3)喷淋、宿舍人数控制、建筑结构优化等安全措施能有效提高人员疏散效果,降低火灾危险性;(4)研究成果能为建筑防火设计、消防整改和宿舍管理提供科学依据。     

The mediating role of coagulation function on the association of prenatal exposure to aflatoxin B1 and postpartum hemorrhage in Guangxi,China

Environmental Science and Pollution Research - Pregnant women are vulnerable to certain environmental agents, one of which is aflatoxin. As one of the most popular aflatoxins, Aflatoxin B1 (AFB1)...