基于GIS的煤矿生产安全管理系统

煤矿生产安全管理系统本着服务矿山、建设数字化矿山的原则，目的是实现矿山安全信息的收集、管理、可视化分析，针对不同的管理层人员的需求提供相关服务，给决策者提供安全策略。利用地理信息系统(GIS)的数据显示、分析能力．并结合网络化的数据库管理系统(DBMS)能很好地实现矿山安全管理系统的各种功能。例如：安全人员人工检测或自动监测仪器检测的数据，经过系统处理后在地图上相关区域标示安全等级和基本安全情况，通过系统的近似分析优化生产区避难所的选址、设置应急路线等。     

Tools for an enhanced solvent properties screening in the early stages of pharmaceutical process development

The objective of this research was the implementation of tools for the evaluation of solvents trough property screening in the early stages of process development. An important feature of the tools is that the implementation of indexes, scores, or weights is avoided. Information already available from the literature was stored in a database in order to turn raw data into decision making information. As a result, a solvent radar chart, a solvent representation table, and a solvent telescopying tool were developed in an ASP.NET application. The synthesis of Propranolol was used as study case in order to explore the selection of solvents in the early stages of process development. The replacement of diethyl ether was possible in the extraction step, while solvent choices were detected for potential telescoping for extraction and crystallisation steps. Solubility was found as a critical parameter in telescoping analysis. The methodology proposed enhanced the view towards a more holistic perspective and a more robust solvent screening process. As a consequence, the next steps into solvent evaluation and process development can be reduced.