The prenatal determination of glucose-6-phosphatase activity by fetal liver biopsy

Two fetuses at risk for glucose-6-phosphatase deficiency had in utero liver biopsies. Analysis of each showed this enzyme activity to be in the normal range and the pregnancies continued. Neither child has any clinical or metabolic evidence of glucose-6-phosphatase deficiency.     

加筋板在复杂载荷下的振动疲劳寿命分析

目的研究航空工程结构部件——加筋板在准静态载荷和随机动载荷联合加载下的振动疲劳寿命预估问题。方法针对某铣制铝合金缺口加筋板,建立有限元模型,并采用时域法进行静动联合加载下的疲劳寿命分析。首先将准静态载荷分解为静力与正弦激励,以静力结果作为平均应力修正S-N曲线,再采用随机响应分析计算动载荷单独作用下结构危险点的应力PSD函数,通过逆傅里叶变换法,提取随机加载过程中的时域信号后,应用Von Mises等效准则,将其与正弦激励时域样本进行叠加,得到疲劳分析应力谱,再结合Miner线性累积理论和雨流循环计数法,计算得加筋板结构静动联合加载下的疲劳寿命。结果通过有限元仿真分析计算,得到加筋板在静动载荷共同作用下的疲劳寿命,对比试验寿命,误差基本在两倍界以内。结论由仿真与试验的结果对比说明,该方法可以有效预估试验件在静动载荷联合加载下的疲劳寿命,并能进一步推广到类似载荷下的疲劳寿命预估问题。     

Hidden Markov models for circular and linear-circular time series

We introduce a new class of circular time series based on hidden Markov models. These are compared with existing models, their properties are outlined and issues relating to parameter estimation are discussed. The new models conveniently describe multi-modal circular time series as dependent mixtures of circular distributions. Two examples from biology and meteorology are used to illustrate the theory. Finally, we introduce a hidden Markov model for bivariate linear-circular time series and use it to describe larval movement of the fly Drosophila. Received: September 2003 / Revised: March 2004