Congenital nephropathy and ventriculomegaly: a report of four cases

Congenital nephrotic syndrome with ventriculomegaly and a normal karyotype is a rare association. We report four cases, three of which were conceived consecutively by one couple. All the cases were associated with elevated maternal serum alpha-fetoprotein. Renal histology in one fetus demonstrated colloid filled cysts distributed in the corticomedullary area. Transmission electron microscopy of the glomeruli showed normally developed foot processes and confirmatory genetic studies excluded Finnish congenital nephrotic syndrome. It is probable that congenital nephropathy in conjunction with ventriculomegaly is the result of an autosomal recessive syndrome. Copyright © 2002 John Wiley & Sons, Ltd.     

安体舒通对2型糖尿病肾病的保护作用

探讨安体舒通对于2型糖尿病肾病患者蛋白尿、血压及肾功能的影响．采用随机双盲交叉的实验方法，20个2型糖尿病肾病患者参与了本课题．在以前降压药的基础上，包括利尿剂、最大推荐剂量的AECI或和ARB，患者以随机的顺序予安体舒通20mg／d及安慰剂分别治疗8周，每个治疗阶段后，测定血压、24h尿蛋白定量及肾小球滤过率（GFR）．安体舒通显著地降低了2型糖尿病肾病患者的血压及24h尿蛋白定量，而肾小球滤过率无显著变化，且24h尿蛋白定量的变化与血压的变化无明显相关．对于2型糖尿病肾病患者，在推荐最大剂量AECI或和ARB的基础上，加用适当剂量的安体舒通有额外的肾脏保护作用．表3，参11．