Increased fetal nuchal fold leading to prenatal diagnosis of ring chromosome 15

We report on the prenatal diagnosis of ring chromosome 15 in a fetus with increased nuchal fold and intrauterine growth restriction (IUGR). A 27-year-old woman gravida 2, para 1 had normal maternal serum screen tests in the early second trimester of the index pregnancy. Fetal nuchal fold thickening up to 8 mm was incidentally found during the routine obstetric ultrasound scan at 20 weeks' gestation. Amniocentesis was undertaken and the fetal karyotype was found to be 46,XY,r(15) on cytogenetic study. Fluorescence in situ hybridization (FISH) using a telomeric probe of chromosome 15 demonstrated a terminal deletion on the q arm of the ring-shaped chromosome 15. This is the first report of a prenatally diagnosed case of ring chromosome 15. Moreover, nuchal fold thickness in the second trimester may have a role in its prenatal diagnosis. Copyright © 2001 John Wiley & Sons, Ltd.     

A first trimester trisomy 13/trisomy 18 risk algorithm combining fetal nuchal translucency thickness,maternal serum free β-hCG and PAPP-A

This study examines 45 cases of trisomy 13 and 59 cases of trisomy 18 and reports an algorithm to identify pregnancies with a fetus affected by trisomy 13 or 18 by a combination of maternal age fetal nuchal translucency (NT) thickness, and maternal serum free β-hCG and PAPP-A at 11–14 weeks of gestation. In this mixed trisomy group the median MoM NT was increased at 2.819, whilst the median MoMs for free β-hCG and PAPP-A were reduced at 0.375 and 0.201 respectively. We predict that with the use of the combined trisomy 13 and 18 algorithm and a risk cut-off of 1 in 150 will for a 0.3% false positive rate allow 95% of these chromosomal defects to be identified at 11–14 weeks. Such algorithms will enhance existing first trimester screening algorithms for trisomy 21. Copyright © 2002 John Wiley & Sons, Ltd.     

曲面零件在拉深过程中内皱时刻及影响因素

进一步推导了曲面零件悬空区上的应力分布及临界失稳公式。然后通过计算机编程 ,求解了临界失稳方程 ,得到了拉深系数、相对锥顶半径、相对圆角半径、材料相对厚度与临界失稳时刻间的关系曲线 ,并对曲线变化的规律进行了分析。     

应用照相法估算高架点源的污染物浓度

应用流体力学基本原理，导出了烟流扩散新模式，讨论了利用照相法估算烟流污染物浓度的方法及步骤，以高架点源烟流扩散为例，应用新模式结合照相法估算烟流污染物浓度，并与利用高斯模式计算的烟流污染物浓度进行比较，结果表明两者吻合较好．     

旋轮形状对杯形件单道次拉深旋压成形的影响

对杯形件单道次拉深旋压成形过程进行了分析,重点讨论了具有两个圆弧工作面的旋轮形状对成形过程的影响.研究结果表明,不同的旋轮形状不仅改变了旋压力p的大小,并且由于其对厚度应变ε的分布影响较大而造成整个旋压过程变形特征的改变,从而导致在工件的不同部位产生破裂.     

填埋场垃圾堆体平面压实工程试验研究

原生垃圾密度很小，为提高填埋垃圾堆体密实度、延长填埋场使用寿命，对填埋垃圾进行压实处理很重要。本文通过现场工程试验对影咱填埋垃圾堆体平面压实效果的主要因素进行了系统研究。实验结果表明：为取得最佳的垃圾堆体平面压实效果，最佳垃圾摊铺厚度在0.5m—0.7m之间，最佳机械行程次数为3次，增加碾压次数有利于提高垃圾堆体密实度，垃圾最佳含水率在30％——50％之间。     

1420Al-Li合金特深模锻件偏心问题分析及对策

对 14 2 0Al Li合金特深模锻件在实际生产 (反挤压 )过程中所产生的偏心问题进行了分析 ,分析表明 ,在上下的方向上 ,润滑不均将使冲头产生弯曲变形和使挤压筒上抬 ,致使锻件产生明显的偏心 ;在左右方向上 ,冲头的轴线相对于挤压筒轴线左偏 ,是产生偏心的主要原因。文中还提出了纠偏的措施。