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Abinesh Bose Najam Akhtar Shakil Pankaj Jitendra Kumar Manish K. Singh 《Journal of environmental science and health. Part. B》2013,48(3):254-261
A series of novel N-alkyl substituted amides, synthesized by enzyme catalysis, were evaluated against root-knot nematode, Meloidogyne incognita and found to have potential antinemic activity. The corresponding amides were prepared by the condensation of equimolar amounts of carboxylic acids with different alkyl amines in the presence of Candida antarctica lipase at 60–90°C in 16–20 h. The reactions were carried out in a non - solvent system without the use of any activating agents. All the products were obtained in appreciable amounts and the yields for different compounds varied between 77.4–82.3%. The synthesized compounds were characterized using spectroscopy techniques namely Infra Red (IR) and Nuclear Magnetic Resonance (NMR) (1H and 13C). Nematicidal activity of synthesized amides was evaluated against J2s of Meloidogyne incognita at 500, 250, 125 and 62.5 ppm concentrations after 24 h, 48 h and 72 h of exposure. Among all the tested compounds, N-propyl-butyramide, N-propyl-pentanamide and N-propyl-hexanamide were found to possess significant activity with LC50 values of 67.46, 83.49 and 96.53 respectively. N-propyl-butyramide with LC50 value of 67.46 ppm was found to be most active amide against J2s of Meloidogyne incognita. The bioactivity study showed that an increase in alkyl chain significantly decreased the activity of amides against root-knot nematode. 相似文献
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