Polybrominated diphenyl ethers and persistent organochlorines in Japanese human adipose tissues |
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Authors: | Kunisue Tatsuya Takayanagi Nozomi Isobe Tomohiko Takahashi Shin Nose Masato Yamada Taketo Komori Hiroaki Arita Norimasa Ueda Norifumi Tanabe Shinsuke |
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Institution: | aCenter for Marine Environmental Studies (CMES), Ehime University, Bunkyo-cho 2-5, Matsuyama 790-8577, Japan;bDepartment of Pathology, Ehime University School of Medicine, Shitsukawa, Toon 791-0295, Japan;cDepartment of Pathology, School of Medicine, Keio University, Shinanomachi 35, Shinjuku-ku 160-8582, Japan |
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Abstract: | The present study determined concentrations of polybrominated diphenyl ethers (PBDEs) and persistent organochlorines (OCs) in Japanese human adipose tissues collected during 2003–2004. Concentrations of PBDEs in adipose tissues were 1–2 orders of magnitude lower than those of OCs. However, observed PBDE congener levels in this study were relatively higher than those in Japanese human adipose tissues collected during 2000 reported previously, while OC levels were comparable to those in specimens collected during 1999 reported by our group. In addition, no age-dependent accumulation of PBDEs was observed, while OC levels except chlordane compounds increased with age. These results indicate recent human exposure to PBDEs in Japan. Among PBDE congeners accumulated in Japanese adipose tissues, BDE-153 was dominant, but this trend was different from those in human milk (BDE-47) and blood (BDE-209) reported previously in Japan, implying the congener-specific kinetics in human bodies. The significant positive correlations between PBDEs and OCs were observed in Japanese adipose tissues, indicating the similar exposure route of these contaminants for Japanese citizens, probably via fish intake. |
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Keywords: | PBDEs OCs Human adipose tissue Japan |
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