| 微塑料在哺乳动物的暴露途径、毒性效应和毒性机制浅述 |
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| 引用本文： | 王英雪,徐熳,王立新,崔建升.微塑料在哺乳动物的暴露途径、毒性效应和毒性机制浅述[J].环境化学,2021,40(1):41-54. |
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| 作者姓名： | 王英雪 徐熳 王立新 崔建升 |
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| 作者单位： | 河北科技大学环境科学与工程学院,河北省污染防治生物技术实验室,石家庄,050018;河北省药用分子化学重点实验室,石家庄,050018;河北科技大学环境科学与工程学院,河北省污染防治生物技术实验室,石家庄,050018;河北省药用分子化学重点实验室,石家庄,050018;河北科技大学环境科学与工程学院,河北省污染防治生物技术实验室,石家庄,050018;河北省药用分子化学重点实验室,石家庄,050018;河北科技大学环境科学与工程学院,河北省污染防治生物技术实验室,石家庄,050018;河北省药用分子化学重点实验室,石家庄,050018 |
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| 基金项目： | 河北省高等学校青年拔尖人才项目(BJ2019033)资助。 |
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| 摘 要： | 微塑料广泛存在于大气、土壤和水体环境中,其对人体的危害正受到广泛关注.本文阐述了当前对微塑料在哺乳动物的暴露途径、毒性作用和毒性机制的认识.空气-呼吸系统、食物/饮水-消化系统以及洗漱/护肤产品-皮肤等都是目前最常见的微塑料人体暴露途径,其中消化系统暴露是最主要的方式.目前的研究显示肠道、肝脏和肾脏是主要的微塑料富集部...
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| 关 键 词： | 微塑料 暴露途径 器官损伤 毒性效应 毒性机制 |
The exposure routes,organ damage and related mechanism of the microplastics on the mammal |
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| WANG Yingxue,XU Man,WANG Lixin,CUI Jiansheng.The exposure routes,organ damage and related mechanism of the microplastics on the mammal[J].Environmental Chemistry,2021,40(1):41-54. |
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| Authors: | WANG Yingxue XU Man WANG Lixin CUI Jiansheng |
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| Institution: | (College of Environmental Science and Engineering,Hebei University of Science and Technology,Pollution Prevention Biotechnology Laboratory of Hebei Province,Shijiazhuang,050018,China;Hei Key Laboratory of Molecular Chemistry for Drug,Shijiazhuang,050018,China) |
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| Abstract: | Microplastics widely exist in the atmosphere, soil and water environment, causing extensive attention to their adverse effects on human health. We here systematically recapitulated the exposure routes of microplastics for human body and the consequent toxic effects on human organs. The exposure routes include digestive tract, respiratory tract and skin, particularly digestive tract. It has been revealed that intestinal tract, liver and kidney are the main enrichment sites of microplastics, leading to intestinal flora imbalance, intestinal function disorder and liver lipid metabolism disorder. However, the toxic effects on other tissues and systems, such as lung, kidney, nervous system and reproductive system, warrant more studies.The underlying toxic mechanisms of microplastics mainly include oxidative stress and inflammatory response. The current review would help advance the systematical understand on the health hazards of microplastics, and provide support for the risk assessment of microplastics in the future. |
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| Keywords: | Microplastics exposure routes organ damage toxic effects toxic mechanisms |
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