肠道微生物与环境健康关系的研究进展与展望

尽管肠道微生物群落在调节宿主多种生理功能的稳态以及抵抗环境污染物的毒性等方面至关重要,但是其在环境健康上的作用直到近几年才引起关注.本综述主要概述了环境污染物对肠道微生物的作用导致的健康效应的最新研究进展.发展迅速的高通量测序平台与合成生态学方法有助于快速确定肠道微生物组成,结合信息化综合分析方法可进一步探明肠道微生物...

Research progress and prospect of relationship between gut microbiota and environmental health

Although gut microbiota communities are crucial in regulating the homeostasis of host physiological functions and resisting the toxicity of environmental pollutants, their role in environmental health has not attracted attention until recently. This review mainly summarized the latest research progress on health effects caused by the effects of environmental pollutants on gut microbiota. The use of high-throughput sequencing platform and synthetic ecology methods had made rapid progress in determining the composition of gut microbiota. The combination of information-based comprehensive analysis methods was helpful to explore the regulation mechanism of intestinal microorganisms on pollutants. Furthermore, this review focused on examples and discussed the mechanism of interaction between heavy metals, organic pollutants, nanoparticles, microplastics and intestinal microbial communities, and its impact on health of hosts. The research on gut microbiota community in environmental health has just started, and there are many scientific and technical difficulties to be overcome. At the end of the review, the author pointed out the prospect of future research contents from the aspects of research objects, technical methods and applications.