| The oxidation damage of type II collagen by oxy free radicals and fulvic acid |
| |
| 作者姓名： | Wang Chunxi Wang Kui Xu Shanjin Zhang Fahao |
| |
| 作者单位： | Wang Chunxia，Wang Kui，Xu Shanjin and Zhang FahaoSchool of Pharmaceutical Sciences and Research Laboratories of Natural and Biomimetic Drugs.Beijing Medical Univesristy，Beijing 100083，China |
| |
| 摘 要： | The features of oxidative damage to type II collagen from pig cartilage, induced by · OH, O2- and fulvic acid from epidemic district of KBD, were studied in vitro. The results from amino acid analysis of the damaged collagen are characterized by a decrease in hydroxyproline and proline contents, and an increase in glutamic acid content. The change arc dependent on·OH and FA concentration. It is postulated that the FA or other toxic xenobiotics induce the generation of free radicals, which play the role of the trigger in KBD development.
|
| 关 键 词： | Kaschin-Beck disease collagen free radicals fulvic acid. |
| 收稿时间： | 1991/7/11 0:00:00 |
The oxidation damage of type II collagen by oxy free radicals and fulvic acid |
| |
| Wang Chunxi,Wang Kui,Xu Shanjin,Zhang Fahao.The oxidation damage of type II collagen by oxy free radicals and fulvic acid[J].Journal of Environmental Sciences,1991,3(4):55-59. |
| |
| Authors: | Wang Chunxia Wang Kui Xu Shanjin and Zhang FahaoSchool of Pharmaceutical Sciences and Research Laboratories of Natural and Biomimetic Drugs |
| |
| Institution: | Wang Chunxia,Wang Kui,Xu Shanjin and Zhang FahaoSchool of Pharmaceutical Sciences and Research Laboratories of Natural and Biomimetic Drugs.Beijing Medical Univesristy,Beijing 100083,China |
| |
| Abstract: | The features of oxidative damage to type II collagen from pig cartilage, induced by · OH, O2- and fulvic acid from epidemic district of KBD, were studied in vitro. The results from amino acid analysis of the damaged collagen are characterized by a decrease in hydroxyproline and proline contents, and an increase in glutamic acid content. The change arc dependent on·OH and FA concentration. It is postulated that the FA or other toxic xenobiotics induce the generation of free radicals, which play the role of the trigger in KBD development. |
| |
| Keywords: | Kaschin-Beck disease collagen free radicals fulvic acid |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《环境科学学报(英文版)》浏览原始摘要信息 |
| 点击此处可从《环境科学学报(英文版)》下载免费的PDF全文 |
