| 汞和镍对人血淋巴细胞转化及DNA合成的效应 |
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| 引用本文： | 张波,孟紫强.汞和镍对人血淋巴细胞转化及DNA合成的效应[J].中国环境科学,1996,16(6):0-0. |
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| 作者姓名： | 张波 孟紫强 |
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| 作者单位： | 山西大学环境科学系 太原030006;山西大学生命科学系 太原030006 |
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| 摘 要： | 通过测定3H－TdR参入细胞DNA的方法研究了氯化汞和氯化镍对人血淋巴细胞转化和DNA合成的效应。结果表明，氯化汞和氯化镍对人外周血淋巴细胞的转化和DNA合成的效应是双相性的：在极低浓度下汞、镍化合物均可促进淋巴细胞转化和DNA合成，而在高浓度下则抑制淋巴细胞转化和DNA合成。汞、镍化合物对淋巴细胞的这种刺激效应比细胞有丝分裂素—植物血凝素（PHA）的刺激效应要弱。汞对细胞转化和DNA合成的刺激效应比镍强
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| 关 键 词： | 汞 镍 淋巴细胞转化 DNA合成 |
| 收稿时间： | 1900-01-01; |
Effects of mercuric and nickel on blast transformation and DNA synthesis of human blood lymphocytes |
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| Zhang Bo and Meng Ziqiang Division of Environmental Biological Toxicology,Shanxi University,Taiyuan.Effects of mercuric and nickel on blast transformation and DNA synthesis of human blood lymphocytes[J].China Environmental Science,1996,16(6):0-0. |
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| Authors: | Zhang Bo and Meng Ziqiang Division of Environmental Biological Toxicology Shanxi University Taiyuan |
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| Institution: | Zhang Bo 1 and Meng Ziqiang 2 1 Division of Environmental Biological Toxicology,Shanxi University,Taiyuan 030006 2 Department of Environmental Science,Shanxi University,Taiyuan 030006 |
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| Abstract: | Effects of mercuric chloride and nickel chloride on blast transformation and DNA synthesis of unsensitized human blood lymphocytes were investigated with determination of 3 H-thymidine ( 3H TdR)incorporation into cellular DNA. The results have shown that effects of mercuric chloride nickel chloride on blast transformation and DNA synthesis of human blood lymphocytes are biphasic:the chemicals at very low concentrations enhance the blast transformation and DNA synthesis, whereas higher concentrations inhibite these processes. The stimulating effects of mercuric and nickel on human lymphocytes are weaker than the lectinic mitogen-PHA The stimulating effect of mercuric on the blast transformation and DNA synthesis is stronger than that of nickel. |
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| Keywords: | mercuric nickel lymphocyte transformation DNA synthesis |
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