|
|||||
|
|
Risk of laryngeal and nasopharyngeal cancer associated with arsenic and cadmium in the Tunisian population |
|
| Authors: | Rim Khlifi Pablo Olmedo Fernando Gil Molka Feki-Tounsi Bouthaina Hammami Ahmed Rebai Amel Hamza-Chaffai |
| Affiliation: | 1. Unit of Marine and Environmental Toxicology, UR 09-03, Sfax University, IPEIS, BP 1172, 3018, Sfax, Tunisia 2. Bioinformatics Unit, Centre of Biotechnology of Sfax, BP 1177, 3018, Sfax, Tunisia 3. Department of Legal Medicine and Toxicology, University of Granada, Granada, Spain 4. Department of Otorhinolaryngology, Habib Borguiba Hospital, Sfax, Tunisia |
| Abstract: | Chronic exposure to heavy metals has long been recognized as being capable of increasing head and neck cancer (HNC) incidence, such as laryngeal (LC) and nasopharyngeal (NPC), among exposed human populations. The aim of the present study was to evaluate the concentrations of arsenic (As) and cadmium (Cd) in the blood of 145 patients (LC and NPC) and 351 controls in order to establish a potential relationship between these factors and the occurrence of LC and NPC. Mean blood levels of As and Cd in patients (5.67 and 3.51 μg/L, respectively) were significantly higher than those of controls (1.57 and 0.74 μg/L, respectively). The blood levels of As and Cd were mostly significantly higher than those of controls (p?p?30 pack years) and occupational exposure (>20 years) presented the most significant association with HNC (OR?=?10.22 and 10.38, respectively, p?p?p?p? |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |