Methods for the transcervical collection of fetal cells during the first trimester of pregnancy |
| |
| Authors: | Professor Charles Rodeck Boris Tutschek Jon Sherlock John Kingdom |
| |
| Institution: | Department of Obstetrics and Gynaecology and Department of Genetics, University College London, London NW1 2HE, U.K. |
| |
| Abstract: | Before termination of pregnancy, four techniques for retrieving fetal cells transcervically were investigated: uterine lavage, endocervical lavage, cytobrush and mucus aspiration. The yield of fetal cells in these samples was studied and found to be somewhat better after uterine lavage. A preliminary assessment of the safety of mucus aspiration was carried out before transcervical chorionic villus sampling (CVS) in continuing pregnancies. No difference in outcome to a control group having only CVS was found. |
| |
| Keywords: | non-invasive prenatal diagnosis transcervical cells (TCCs) collection techniques |
|
