| 硝基多环芳烃的致突变性与理化参数之间的定量结构活性关系 |
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| 引用本文： | 余刚,徐晓白. 硝基多环芳烃的致突变性与理化参数之间的定量结构活性关系[J]. 重庆环境科学, 1994, 0(2) |
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| 作者姓名： | 余刚 徐晓白 |
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| 作者单位： | 清华大学环境工程系，中国科学院生态环境研究中心 |
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| 摘 要： | 硝基多环芳烃因具有直接致突变性、潜在致癌性以及在环境中的广泛存在而引起人们的关注。本文在硝基多环芳烃的致突变活性与理化参数（正辛醇－水分配系数、水溶解度、分子连接性指数）之间建立了１０个定量结构活性关系式。并利用溶解度与致突变性之间的结构活性关系对５０种硝基多环芳烃的致突变能力进行预测，正确率达７８％。
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| 关 键 词： | 硝基多环芳烃，致突变性，理化参数，定量结构活性关系 |
THE QSARS BETWEEN MUTAGENICITIES AND PARAMETER OF NITRO-PAHS |
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| yu Gang. THE QSARS BETWEEN MUTAGENICITIES AND PARAMETER OF NITRO-PAHS[J]. Chongqing Environmental Science, 1994, 0(2) |
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| Authors: | yu Gang |
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| Affiliation: | yu Gang(Department of Environmental Engineering. Tsinghua University Beijing)Xu Xiaobai(Research Center for Eco-environmental Sciences . Academia Sinica Beijing) |
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| Abstract: | Nitrated polycyclic aromatic hyerocarbons( nitro-PAHs ) are a class of important pollutants with significant direct-ac ting rnntagenicity and potential car-cinogenicity.They have been detected in many environmental sam ples. such as air particuiates. diesel engine exhausts. river sediments. etc.This paper mainly conc-erns with some of the struct ure-activity relationships of nitor-pAHs.10 Linear equations of qnantitive structure-activity relationships between the parameter and mutagenicities of nitro-PAHs were described.The mutagenicities of 50 nitro-PAHs were predicted from their solubilities for the first time with satisfaction. |
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| Keywords: | Nitrated PAHs Mutagenicity Physico-chemical Parameter Quan-titative Structure-activity Relationships(QSARs ) |
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