Acute oral toxicity as LD50 (mg/kg) of propargyl alcohol to male and female rats

Dosages of propargyl alcohol ranging from 0 to 400 mg/kg in 0.5 ml aqueous solutions were administered by gavage to young adult male and female rats of the Sprague-Dawley strain weighing from 180 to 200 g. The treated animals were held 48 hrs at 24 degrees C with food and water ad libitum, after which the dead rats were counted. The oral LD50 was calculated by the probit method (Finney, 1971) as 110 (100-120) mg/kg for male rats and 55 (50-60) mg/kg for female rats.