| 共存氯代酚结构对1-NP致突变性的影响 |
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| 引用本文： | 张朝,竺乃恺,杜秀英,夏希娟,黄国兰.共存氯代酚结构对1-NP致突变性的影响[J].环境化学,2000,19(6):550-555. |
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| 作者姓名： | 张朝 竺乃恺 杜秀英 夏希娟 黄国兰 |
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| 作者单位： | 1. 中国科学院生态环境研究中心,北京,100085
2. 南开大学环境科学与工程学院,天津,310072 |
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| 基金项目： | 中国科学院资助项目，中国科学院资助项目，29837180，KZ951-B/209-06，， |
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| 摘 要： | 研究了氯代酚与1－NP的单一和联合致突变效应，结果发现，各氯代酚对1－NP的致突变性有不同程度的抑制作用，且抑制效应系数（S）与各氯代酚的分子描述参数的关系能用QSAR方程表示，由方程得出的预测值与实验测定值之间能较好地吻合。
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| 关 键 词： | 氯代酚 联合致突变 QSAR方程 1－NP 环境毒理 |
THE RESEARCH ON THE EFFECT OF STRUCTURES OF ECO-CHLOROPHENOLS ON THE MUTAGENICITY OF 1-NP USING QSAR |
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| Zhang Zhao,Zhu Naikai,Du Xiuying,Xia Xijuan,Huang Guolan.THE RESEARCH ON THE EFFECT OF STRUCTURES OF ECO-CHLOROPHENOLS ON THE MUTAGENICITY OF 1-NP USING QSAR[J].Environmental Chemistry,2000,19(6):550-555. |
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| Authors: | Zhang Zhao Zhu Naikai Du Xiuying Xia Xijuan Huang Guolan |
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| Abstract: | The single and joint mutagenicities of 1-NP and chlorophenols were studied. Results showed that chlorophenols are low-mutagenicities ( ) except 2, 3-DCP and 2,3, 5-TCP ( - ), all the chlorophenols inhibit the mutagenicity of 1-NP to some degree. Using QSAR analysis, good linear relationship were found between joint mutagenicities and molecular parameters of chlorophenols. The experimental and predicted values from the QSAR equations are agreeable to experimental ones. |
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| Keywords: | inhibitive effect value joint mutagenicity 1-NP chlorophenols QSAR |
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