Microsatellite length polymorphisms associated with dispersal-related agonistic onset in male wild house mice (Mus musculus domesticus) |
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Authors: | Sven Krackow Barbara König |
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Institution: | 1. Zoologisches Institut, Universit?t Zürich, Winterthurerstrasse 190, 8057, Zürich, Switzerland 2. Institut für Biologie, Humboldt-Universit?t zu Berlin, Invalidenstrasse 43, 10115, Berlin, Germany
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Abstract: | Dispersal propensity, reflecting one of the most decisive mammalian life history traits, has been suggested to vary heritably
and to locally adapt to prevailing dispersal conditions in wild house mouse populations. Because individual dispersal propensity
highly significantly covaries with the developmental timing of the onset of agonistic interactions between littermate brothers,
we used agonistic onset as an endophenotype to explore the potential genetic basis of dispersal-related behavioral variation
in male house mice. We found significant covariation of microsatellite marker compositions with the probability of fraternal
pairs to exhibit agonistic relationships before the age of 2 months. In particular, the presence of two alleles associated
with a serotonin transporter protein gene (Slc6a4) and a testosterone dehydrogenase gene (Cyp3a11), respectively, strongly
covaried with the probability of early agonistic onset. These results are congruent with recent findings of microsatellite
length polymorphisms marking regulatory variation of gene expression that is relevant for social behavior, including dispersal
propensity development, in other mammals. Genetic variability for ontogenetic timing of agonistic onset would be in agreement
with genotypic differentiation of the dispersive behavioral syndrome in natural populations that could lead to local adaptation. |
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Keywords: | Dispersive behavioral syndrome Serotonin transporter protein Slc6a4 Steroid inducible cytochrome P450 Cyp3a11 |
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