Isolation and identification of new vasodilative substances in diesel exhaust particles |
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| Authors: | Seki Koh-ichi Noya Yoichi Mikami Yusuke Taneda Shinji Suzuki Akira K Kuge Yuji Ohkura Kazue |
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| Institution: | (1) Central Institute of Isotope Science, Graduate School of Medicine, Hokkaido University, Sapporo 060-0815, Japan;(2) Department of Radiopharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Ishikari-Tobetsu 061-0293, Japan;(3) Environmental Nanotoxicology Section, Research Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba 305-8506, Japan |
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| Abstract: | Background, aim, and scope We recently developed a new isolation method for diesel exhaust particles (DEP), involving successive extraction with H2O, sodium bicarbonate, and sodium hydroxide, in which the sodium hydroxide extract was found to consist of phenolic components.
Analysis of the extract revealed that vasodilative-active nitrophenols are in DEP in significantly higher concentrations than
those estimated by an earlier method involving a combination of solvent extraction and repeated chromatography. These findings
indicated that our new procedure offers a simple, efficient, and reliable method for the isolation and identification of bioactive
substances in DEP. This encouraged us to extend our work toward investigating new vasodilatory substances in the sodium bicarbonate
extract. |
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