Mechanism of formation of SCH3-metabolites investigated on the biotransformation of 1-allyl-3,5-diethyl-6-chlorouracil in rabbits |
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| Authors: | R Kaul G Kiefer B Hempel |
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| Institution: | Research Laboratories, Pharmaceuticals Robugen GmbH Postfach 266, D-73 Esslingen/N, West Germany |
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| Abstract: | A new S-containing metabolite of 1-allyl-3,5-diethyl-6-chlorouracil is reported. By comparison with an authentic sample, this metabolite has been identified as 6,8-diethyl-2-hydroxymethyl-tetrahydrothiazolo 3,2-c] pyrimidine-5,7 (4H, 6H)-dione. The mechanism of the formation of S-containing metabolites is discussed. |
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