Biomedical Research Center, Slovak Academy of Sciences, Bratislava, Slovakia;2. Institute of Medical Biochemistry and Laboratory Diagnostics, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic;3. Department of Obstetrics and Gynecology, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic;4. Institute of Molecular Biomedicine, Faculty of Medicine, Comenius University, Bratislava, Slovakia