Extending the Dewanji and Kalbfleisch model to incorporate marker data |
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| Authors: | Alex McMillan Abraham Silvers |
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| Institution: | (1) Cancer Center, University of California, 94143-1297 San Francisco, CA, USA;(2) Department of Epidemiology and Biostatistics, University of California, 94143-1297 San Francisco, CA, USA |
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| Abstract: | The model of Dewanji and Kalbfleisch for the estimation of time to tumour onset from a serial-sacrifice experiment is extended to include a marker state prior to the onset of the tumour. There are two versions of the model, one where a tumour is allowed to develop without the onset of marker, the other where a tumour develops after the marker but in which the marker later becomes unobservable. |
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| Keywords: | Carcinogenesis models formaldehyde risk assessment rodent serial sacrifice experiments squamous cell carcinoma squamous metaplasia |
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