Prolonged manganese exposure induces severe deficits in lifespan, developmentand reproduction possibly by altering oxidative stress responsein Caenorhabditis elegans |
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Authors: | XIAO Jing RUI Qi GUO Yuling CHANG Xingya WANG Dayong |
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Affiliation: | 1. College of Life Sciences,Nanjing Normal University,Nanjing 210046,China;Department of Genetics and Developmental Biology,Southeast University,Nanjing 210009,China;Key Laboratory of Developmental Genes and Human Disease in Ministry of Education,Nanjing 21 2. Department of Genetics and Developmental Biology,Southeast University,Nanjing 210009,China;Key Laboratory of Developmental Genes and Human Disease in Ministry of Education,Nanjing 210009,China |
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Abstract: | We examined the possible multiple defects induced by acute and prolonged exposure to high levels of manganese (Mn) solution by monitoring the endpoints of lifespan,development,reproduction,and stress response.Our data suggest that acute exposure (6 h) to Mn did not cause severe defects of life span,development,and reproduction.Similarly,no significant defects could be found for the life span,development,and reproduction in animals exposed to a low concentration of Mn (2.5 μmol/L) for 48 h.In contrast,prolonged exposure (48-h) to high concentrations of Mn (75 and 200 μmol/L) resulted in significant defects of life span,development,and reproduction,as well as the increase of the percentage of population with hsp-16.2::gfp expression indicating the obvious induction of stress responses in exposed animals.Moreover,prolonged exposure (48-h) to high concentrations (75 and 200 μmol/L) of Mn decreased the expression levels of antioxidant genes of sod-1,sod-2,sod-3,and sod-4 compared to control.Therefore,prolonged exposure to high concentrations of Mn will induce the severe defects of life span,development,and reproduction in nematodes possibly by affecting the stress response and expression of antioxidant genes in Caenorhabditis elegans. |
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Keywords: | manganese toxicity prolonged exposure stress response antioxidant gene Caenorhabditis elegans |
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